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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7472 7-Hydroxyflavone 6665-86-7 98%
7-Hydroxyflavone
7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammator...
T7132 (Rac)-Brassinazole 224047-41-0 98%
(Rac)-Brassinazole
(Rac)-Brassinazole are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell divisio...
T5594 Cedrol 77-53-2 98%
Cedrol
Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respective...
T2305 Isavuconazole 241479-67-4 98%
Isavuconazole
Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004...
T8125 Quinidine sulfate dihydrate 6591-63-5 98%
Quinidine sulfate dihydrate
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor
T7427 1-Ethynylnaphthalene 15727-65-8 98%
1-Ethynylnaphthalene
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1
T12146 N-Desmethyl-Apalutamide 1332391-11-3 97.83%
N-Desmethyl-Apalutamide
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
T6246 Cobicistat 1004316-88-4 97.79%
Cobicistat
Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, ...
TN1702 Glycycoumarin 94805-82-0 97.64%
Glycycoumarin
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
T3696 Polygalaxanthone III 162857-78-5 97.54%
polygalaxanthone III
Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
T2196 Fipronil 120068-37-3 97.48%
Fipronil
Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disr...
T30161 EN3356 1429329-63-4 97.47%
EN3356
EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzym...
T37332 (±)-N-3-Benzylnirvanol 93879-40-4 97.16%
(±)-N-3-Benzylnirvanol
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll. (+) -n-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll are sele...
T26322L (-)-Vorozole 132042-69-4 97.14%
(-)-Vorozole
(-)-Vorozole is an orally active non-steroidal aromatase inhibitor with potency and selectivity. (-)-Vorozole has demonstrated antitumor activity in in vivo expe...
T4188 SDZ285428 174262-13-6 96.91%
SDZ285428
SDZ285428 is a CYP24A1 inhibitor.
T50001 Tinoridine 24237-54-5 95.00%
Tinoridine
Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2). It has anti-inflammatory, anti-allergic and antic...
T50053 Lofemizole 65571-68-8 95.00%
Lofemizole
Lofemizole is an antagonist of CYP1A2.
T5S2343 Acetylshikonin 24502-78-1 92.45%
Acetylshikonin
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
T3002 Piperine 94-62-2 100%
Piperine
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
T23549 YM 511 148869-05-0 100%
YM 511
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
7-Hydroxyflavone
T7472
7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammator...
(Rac)-Brassinazole
T7132
(Rac)-Brassinazole are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell divisio...
Cedrol
T5594
Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respective...
Isavuconazole
T2305
Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004...
Quinidine sulfate dihydrate
T8125
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor
1-Ethynylnaphthalene
T7427
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1
N-Desmethyl-Apalutamide
T12146
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
Cobicistat
T6246
Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, ...
Glycycoumarin
TN1702
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
polygalaxanthone III
T3696
Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
Fipronil
T2196
Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disr...
EN3356
T30161
EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzym...
(±)-N-3-Benzylnirvanol
T37332
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll. (+) -n-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll are sele...
(-)-Vorozole
T26322L
(-)-Vorozole is an orally active non-steroidal aromatase inhibitor with potency and selectivity. (-)-Vorozole has demonstrated antitumor activity in in vivo expe...
SDZ285428
T4188
SDZ285428 is a CYP24A1 inhibitor.
Tinoridine
T50001
Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2). It has anti-inflammatory, anti-allergic and antic...
Lofemizole
T50053
Lofemizole is an antagonist of CYP1A2.
Acetylshikonin
T5S2343
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
Piperine
T3002
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
YM 511
T23549
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
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TargetMol