P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T3811	Ginsenoside C-K	39262-14-1	99.65%
T3811	Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T21818	Pregnenolone Carbonitrile	1434-54-4	99.64%
T21818	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
TQ0296L	N-Nornuciferine hydrochloride(4846-19-9 free base)	TQ0296L	99.63%
TQ0296L	N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3...
T6S0630	Hypaconitine	6900-87-4	99.63%
T6S0630	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T6246	Cobicistat	1004316-88-4	99.62%
T6246	Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, ...
T0679	Ketoconazole	65277-42-1	99.62%
T0679	Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T27918	LY 43578	26766-35-8	99.62%
T27918	LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (I...
T22254	Alflutinib	1869057-83-9	99.61%
T22254	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.
T3698	Alpha-Asarone	2883-98-9	99.59%
T3698	alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
T6509	Galeterone	851983-85-2	99.57%
T6509	Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galetero...
T22391	Omeprazole Sodium	95510-70-6	99.57%
T22391	Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibit...
T20656	Verapamil	52-53-9	99.53%
T20656	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies ab...
T2S0663	Humantenmine	82354-38-9	99.51%
T2S0663	1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
T0182L	Clopidogrel hydrogen sulfate	120202-66-6	99.51%
T0182L	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
T5786	TETRAHYDROPIPERINE	23434-88-0	99.51%
T5786	Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T37826	CAY10462	502656-68-0	99.49%
T37826	CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM. CAY10462 exhibits nearly 200 times less pote...
T11991	Mefentrifluconazole	1417782-03-6	99.45%
T11991	Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.9...
T3585	TMS	24144-92-1	99.42%
T3585	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
T5778	5,7-DIMETHOXYFLAVONE	21392-57-4	99.41%
T5778	5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.
T6030	XL388	1251156-08-7	99.39%
T6030	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.