P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T0765	Fomepizole	7554-65-6	99.94%
T0765	Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competiti...
T21482	Uniconazole	83657-22-1	99.94%
T21482	Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, ac...
TQ0191	Dihydromethysticin	19902-91-1	99.94%
TQ0191	Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23.
T1274	Benzbromarone	3562-84-3	99.94%
T1274	Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.
T4498	Stiripentol	49763-96-4	99.93%
T4498	Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (compe...
T2S1434	Bergaptol	486-60-2	99.92%
T2S1434	1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.
T37784	2,6-Dimethylquinoline	877-43-0	99.92%
T37784	2,6-Dimethylquinoline is a natural product extracted from the roots of Peucedantu praeruptorum. 2,6-Dimethylquinoline is an inhibitor of CYP1A2 and CYP2B6 with ...
T2926	Schizandrin A	61281-38-7	99.91%
T2926	Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM ...
T0603	Phthalic acid mono-2-ethylhexyl ester	4376-20-9	99.91%
T0603	Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 ...
T1540	Doxepin hydrochloride	1229-29-4	99.91%
T1540	Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation....
TN1854	Lasiodin	28957-08-6	99.90%
TN1854	Lasiodin (Lasiokaurin) is a diterpene compound from the plant Camellia sinensis that inhibits the proliferation of NPC cells. Lasiodin has antioxidant, antitumor...
T2946	Tanshinone IIA sulfonate sodium	69659-80-9	99.9%
T2946	Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent neg...
T1415	Gemfibrozil	25812-30-0	99.9%
T1415	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation a...
T1434	Clarithromycin	81103-11-9	99.89%
T1434	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A In...
T26322	Vorozole	129731-10-8	99.89%
T26322	Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the...
T3776	Rhapontigenin	500-65-2	99.88%
T3776	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates pol...
T22003	2,3-dihydrothieno-Thiadiazole Carboxylate	152467-47-5	99.88%
T22003	2,3-dihydrothieno-Thiadiazole Carboxylate is a CYP450 (CYP2E1 and CYP2B4) inhibitor.
T7699	AZD7325	942437-37-8	99.88%
T7699	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
T1187	Bifonazole	60628-96-8	99.87%
T1187	Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the prod...
T6216	Abiraterone	154229-19-3	99.87%
T6216	Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).