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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN4435 Licopyranocoumarin 117038-80-9 98%
Licopyranocoumarin
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
TN1526 Corydalmine 30413-84-4 98%
Corydalmine
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor...
TQ0276 Methysticin 20697-20-5 98%
Methysticin
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
TN3875 Dipterocarpol 471-69-2 98%
Dipterocarpol
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN1210 2-Hydroxy-1-Methoxyaporphine 33770-27-3 98%
2-Hydroxy-1-Methoxyaporphine
2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
T10535L BI 653048 phosphate 1198784-97-2 98%
BI 653048 phosphate
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
TN1748 Humantenirine 82375-30-2 98%
Humantenirine
Humantenirine is a natural product of Gelsemium, Loganiaceae. The catalog number is TN1748 and the CAS number is 82375-30-2. Humantenirine can be used as a refer...
TN3627 Chalepensin 13164-03-9 98%
Chalepensin
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
TN3147 6',7'-Dihydroxybergamottin 264234-05-1 98%
6',7'-Dihydroxybergamottin
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN3574 Canadine 5096-57-1 98%
Canadine
Canadine has antioxidant activity with low-toxic effect.
T10688 Casopitant mesylate 414910-30-8 98%
Casopitant mesylate
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
TN4130 Germacrone 4,5-epoxide 92691-35-5 98%
Germacrone 4,5-epoxide
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
T14678 BMS-819881 1197420-05-5 98%
BMS-819881
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
T5S0669 Bergamottin 7380-40-7 99.99%
Bergamottin
1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-Aydiabetic mic...
T2088 APD668 832714-46-2 99.97%
APD668
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.
T1149 Fenofibrate 49562-28-9 99.97%
Fenofibrate
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyp...
T10953 Dafadine-A 1065506-69-5 99.96%
Dafadine-A
Dafadine-A is an analog of dafadine and a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Mammalian orthologs that also inhibit ...
T8937 Soticlestat 1429505-03-2 99.95%
Soticlestat
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research...
T0920 Ambroxol 18683-91-5 99.95%
Ambroxol
Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of...
T3158L Harman hydrochloride 21655-84-5 99.95%
Harman hydrochloride
Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenic...
Licopyranocoumarin
TN4435
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
Corydalmine
TN1526
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor...
Methysticin
TQ0276
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
Dipterocarpol
TN3875
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
2-Hydroxy-1-Methoxyaporphine
TN1210
2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
BI 653048 phosphate
T10535L
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
Humantenirine
TN1748
Humantenirine is a natural product of Gelsemium, Loganiaceae. The catalog number is TN1748 and the CAS number is 82375-30-2. Humantenirine can be used as a refer...
Chalepensin
TN3627
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
6',7'-Dihydroxybergamottin
TN3147
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
Canadine
TN3574
Canadine has antioxidant activity with low-toxic effect.
Casopitant mesylate
T10688
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
Germacrone 4,5-epoxide
TN4130
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
BMS-819881
T14678
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
Bergamottin
T5S0669
1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mic...
APD668
T2088
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.
Fenofibrate
T1149
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyp...
Dafadine-A
T10953
Dafadine-A is an analog of dafadine and a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Mammalian orthologs that also inhibit ...
Soticlestat
T8937
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research...
Ambroxol
T0920
Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of...
Harman hydrochloride
T3158L
Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenic...
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TargetMol