P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T72501	CYP4A11/CYP4F2-IN-1	502654-40-2	98%
T72501	CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebro...
T73042	CYP1B1-IN-5	176442-56-1	98%
T73042	CYP1B1-IN-5 is a selective and potent cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM.CYP1B1-IN-5 can be used for the study of metabolism-related d...
T67916	CYP4A11/CYP4F2-IN-2	2126874-77-7	98%
T67916	CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CY...
T5953	1-Aminobenzotriazole	1614-12-6	98%
T5953	1-Aminobenzotriazole (ABT) (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.
T0660	Beta-Tetralone	530-93-8	98%
T0660	Beta-Tetralone (2-Tetralone) is a ketone derivative of tetralin.
T1443	Memantine hydrochloride	41100-52-1	98%
T1443	Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
T36125	Tienilic Acid	40180-04-9	98%
T36125	Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity
T19526	Pradefovir mesylate	625095-61-6	98%
T19526	Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.
TN1011	Rhodionin	85571-15-9	98%
TN1011	Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
T21425	Mephenytoin	50-12-4	98%
T21425	Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.
T7056	Dronedarone	141626-36-0	98%
T7056	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T3941	Choline Fenofibrate	856676-23-8	98%
T3941	Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity...
T3668	Galangin	548-83-4	98%
T3668	Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T67926	(S)-(+)-N-3-Benzylnirvanol	790676-40-3	98%
T67926	(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) is a cytochrome P450 CYP2C19 inhibitor with an IC50 value of 0.179 µM that can be used to study HIV infection.
TN1078	Seneciphylline	480-81-9	98%
TN1078	Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significa...
TN1482	Chamaechromone	93413-00-4	98%
TN1482	Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.
T117521	7-BFC	220001-53-6	98%
T117521	7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) is a coumarin-like fluorescent substrate that serves as a biomarker for cytochrome P 450 and can be used to study...
T9704	1-Ethynylpyrene	34993-56-1	98%
T9704	1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).
T0293	Metyrapone	54-36-4	98%
T0293	Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the ...