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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T8125 Quinidine sulfate dihydrate 6591-63-5 98%
Quinidine sulfate dihydrate
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor
T7427 1-Ethynylnaphthalene 15727-65-8 98%
1-Ethynylnaphthalene
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1
T12146 N-Desmethyl-Apalutamide 1332391-11-3 97.83%
N-Desmethyl-Apalutamide
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
TN1702 Glycycoumarin 94805-82-0 97.64%
Glycycoumarin
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
T30161 EN3356 1429329-63-4 97.47%
EN3356
EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzym...
TJS1159 Chrysosplenetin 603-56-5 97.43%
Chrysosplenetin
Chrysosplenetin is a metabolic inhibitor of artemisinin.
T0660 Beta-Tetralone 530-93-8 97.26%
Beta-Tetralone
Beta-Tetralone (2-Tetralone) is a ketone derivative of tetralin.
T37332 (±)-N-3-Benzylnirvanol 93879-40-4 97.16%
(±)-N-3-Benzylnirvanol
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll. (+) -n-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll are sele...
T26322L (-)-Vorozole 132042-69-4 97.14%
(-)-Vorozole
(-)-Vorozole is an orally active non-steroidal aromatase inhibitor with potency and selectivity. (-)-Vorozole has demonstrated antitumor activity in in vivo expe...
T4188 SDZ285428 174262-13-6 96.91%
SDZ285428
SDZ285428 is a CYP24A1 inhibitor.
T50001 Tinoridine 24237-54-5 95.00%
Tinoridine
Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2). It has anti-inflammatory, anti-allergic and antic...
T50053 Lofemizole 65571-68-8 95.00%
Lofemizole
Lofemizole is an antagonist of CYP1A2.
T5S2343 Acetylshikonin 24502-78-1 92.45%
Acetylshikonin
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
T3002 Piperine 94-62-2 100%
Piperine
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
T23549 YM 511 148869-05-0 100%
YM 511
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
T1011 Itraconazole 84625-61-6 100%
Itraconazole
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T1704 Diosmetin 520-34-3 100%
Diosmetin
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
T3797 Isosilybin 72581-71-6 100%
Isosilybin
Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patien...
TN1724 Harmalol hydrochloride 6028-07-5 100%
Harmalol hydrochloride
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is th...
T7725 Albaconazole 187949-02-6 100%
Albaconazole
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, s...
Quinidine sulfate dihydrate
T8125
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor
1-Ethynylnaphthalene
T7427
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1
N-Desmethyl-Apalutamide
T12146
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
Glycycoumarin
TN1702
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
EN3356
T30161
EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzym...
Chrysosplenetin
TJS1159
Chrysosplenetin is a metabolic inhibitor of artemisinin.
Beta-Tetralone
T0660
Beta-Tetralone (2-Tetralone) is a ketone derivative of tetralin.
(±)-N-3-Benzylnirvanol
T37332
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll. (+) -n-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll are sele...
(-)-Vorozole
T26322L
(-)-Vorozole is an orally active non-steroidal aromatase inhibitor with potency and selectivity. (-)-Vorozole has demonstrated antitumor activity in in vivo expe...
SDZ285428
T4188
SDZ285428 is a CYP24A1 inhibitor.
Tinoridine
T50001
Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2). It has anti-inflammatory, anti-allergic and antic...
Lofemizole
T50053
Lofemizole is an antagonist of CYP1A2.
Acetylshikonin
T5S2343
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
Piperine
T3002
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
YM 511
T23549
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
Itraconazole
T1011
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Diosmetin
T1704
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
Isosilybin
T3797
Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patien...
Harmalol hydrochloride
TN1724
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is th...
Albaconazole
T7725
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, s...
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TargetMol