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P2X Receptor

The ATP-gated P2X receptor cation channel family, or simply P2X receptor family, consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T21659 AZ 11645373 227088-94-0 99.36%
AZ 11645373
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor ...
T27683 JNJ-42253432 1428327-35-8 99.08%
JNJ-42253432
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels....
T19839 Oxatomide 60607-34-3 98.93%
Oxatomide
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomid...
T2087 AF-353 865305-30-2 98.81%
AF-353
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T2694 KN-62 127191-97-3 98.77%
KN-62
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
T10466 BAY-1797 2055602-83-8 98.74%
BAY-1797
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
T9519 Eliapixant 1948229-21-7 98.65%
Eliapixant
Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refra...
T67885 Camlipixant 1621164-74-6 98.24%
Camlipixant
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP...
T8436 Minodronic acid 180064-38-4 98.02%
Minodronic acid
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducin...
T14076 A 839977 870061-27-1 98.01%
A 839977
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor ...
T1352 ATP disodium salt 987-65-5 98%
ATP disodium salt
ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.
T4S0536 Bullatine A 1354-84-3 98%
Bullatine A
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treat...
T8946 Indophagolin 1207660-00-1 97.84%
Indophagolin
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
T1131 Ivermectin 70288-86-7 97.31%
Ivermectin
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
TP2226 BzATP triethylammonium salt 112898-15-4 96.26%
BzATP triethylammonium salt
BzATP triethylammonium salt is a P2X7 receptor agonist.
TQ0002 A-317491 475205-49-3 96.1%
A-317491
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T8635 CI 75300 94875-80-6 95.00%
CI 75300
CI 75300 targets the P2X purinoceptor 7 (human).
T8333 Aurintricarboxylic acid 4431-00-9 95%
Aurintricarboxylic acid
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
T2806 Lappaconitine 32854-75-4 92.57%
Lappaconitine
Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
T7881 CTP disodium dihydrate 81012-87-5 100%
CTP disodium dihydrate
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
AZ 11645373
T21659
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor ...
JNJ-42253432
T27683
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels....
Oxatomide
T19839
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomid...
AF-353
T2087
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
KN-62
T2694
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
BAY-1797
T10466
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
Eliapixant
T9519
Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refra...
Camlipixant
T67885
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP...
Minodronic acid
T8436
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducin...
A 839977
T14076
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor ...
ATP disodium salt
T1352
ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.
Bullatine A
T4S0536
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treat...
Indophagolin
T8946
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
Ivermectin
T1131
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
BzATP triethylammonium salt
TP2226
BzATP triethylammonium salt is a P2X7 receptor agonist.
A-317491
TQ0002
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
CI 75300
T8635
CI 75300 targets the P2X purinoceptor 7 (human).
Aurintricarboxylic acid
T8333
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
Lappaconitine
T2806
Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
CTP disodium dihydrate
T7881
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
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TargetMol