T21659 |
AZ 11645373
|
227088-94-0
|
99.36%
|
|
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor ...
|
T27683 |
JNJ-42253432
|
1428327-35-8
|
99.08%
|
|
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels....
|
T19839 |
Oxatomide
|
60607-34-3
|
98.93%
|
|
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomid...
|
T2087 |
AF-353
|
865305-30-2
|
98.81%
|
|
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
|
T2694 |
KN-62
|
127191-97-3
|
98.77%
|
|
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
|
T10466 |
BAY-1797
|
2055602-83-8
|
98.74%
|
|
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
|
T9519 |
Eliapixant
|
1948229-21-7
|
98.65%
|
|
Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refra...
|
T67885 |
Camlipixant
|
1621164-74-6
|
98.24%
|
|
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP...
|
T8436 |
Minodronic acid
|
180064-38-4
|
98.02%
|
|
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducin...
|
T14076 |
A 839977
|
870061-27-1
|
98.01%
|
|
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor ...
|
T1352 |
ATP disodium salt
|
987-65-5
|
98%
|
|
ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.
|
T4S0536 |
Bullatine A
|
1354-84-3
|
98%
|
|
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treat...
|
T8946 |
Indophagolin
|
1207660-00-1
|
97.84%
|
|
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
|
T1131 |
Ivermectin
|
70288-86-7
|
97.31%
|
|
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
|
TP2226 |
BzATP triethylammonium salt
|
112898-15-4
|
96.26%
|
|
BzATP triethylammonium salt is a P2X7 receptor agonist.
|
TQ0002 |
A-317491
|
475205-49-3
|
96.1%
|
|
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
|
T8635 |
CI 75300
|
94875-80-6
|
95.00%
|
|
CI 75300 targets the P2X purinoceptor 7 (human).
|
T8333 |
Aurintricarboxylic acid
|
4431-00-9
|
95%
|
|
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
|
T2806 |
Lappaconitine
|
32854-75-4
|
92.57%
|
|
Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
|
T7881 |
CTP disodium dihydrate
|
81012-87-5
|
100%
|
|
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
|