Home Tools
Log in
Cart

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1310 2-Thiouracil 141-90-2 99.33%
2-Thiouracil
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
TN4234 Hydrangenol 480-47-7 99.33%
Hydrangenol
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
T5S0754 Isoquercetin 482-35-9 99.29%
Isoquercetin
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
T7461 2,4-Diamino-6-hydroxypyrimidine 56-06-4 99.26%
2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
T9376 Nitroarginine 2149-70-4 99.21%
Nitroarginine
Nitroarginine (N'-Nitro-L-arginine) is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells[1].
T21546 NG,NG-dimethyl-L-Arginine dihydrochloride 220805-22-1 99.18%
NG,NG-dimethyl-L-Arginine dihydrochloride
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to ...
TN1516 Cnidicin 14348-21-1 99.16%
Cnidicin
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 mi...
T2S2335 Dehydroevodiamine 67909-49-3 99.12%
Dehydroevodiamine
Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, ...
T5S1389 Escin IB 26339-90-2 99.09%
Escin IB
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to a...
T21507 7-Ethoxyresorufin 5725-91-7 99.09%
7-Ethoxyresorufin
7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
TN1817 Kaempferol 3,7,4'-trimethyl ether 15486-34-7 99.05%
Kaempferol 3,7,4'-trimethyl ether
Kaempferol 3,7,4'-trimethyl ether (Kaempferol 3,7,4'-trimethylether) shows selective cyctoxic activities against the nine tested cancer cell lines.
T77499 MSU-42011 2456434-36-7 99.04%
MSU-42011
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T2S0765 Epibetulinic acid 38736-77-5 99.02%
Epibetulinic acid
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
TN1021 Secologanic acid 60077-46-5 98.99%
Secologanic acid
Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.
TN1934 Mogroside IIA1 88901-44-4 98.98%
Mogroside IIA1
Mogroside IIA1 (Mogroside II-A1) is isolated from the fruits of Siraitia grosvenorii. Mogroside IIA1 is a a nonsugar sweetener and sweeter than sucrose. Mogrosid...
T19032 Nitro blue tetrazolium chloride 298-83-9 98.93%
Nitro blue tetrazolium chloride
Nitro blue tetrazolium chloride (NBT) is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 M). A well-known scavenger of...
TN1134 Euscaphic acid 53155-25-2 98.93%
Euscaphic acid
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
TN1675 Gardenin B 2798-20-1 98.71%
Gardenin B
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T1322 Bendazol 621-72-7 98.7%
Bendazol
Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.
T6S1665 Irisflorentin 41743-73-1 98.6%
Irisflorentin
1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-...
2-Thiouracil
T1310
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
Hydrangenol
TN4234
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
Isoquercetin
T5S0754
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
2,4-Diamino-6-hydroxypyrimidine
T7461
2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
Nitroarginine
T9376
Nitroarginine (N'-Nitro-L-arginine) is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells[1].
NG,NG-dimethyl-L-Arginine dihydrochloride
T21546
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to ...
Cnidicin
TN1516
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 mi...
Dehydroevodiamine
T2S2335
Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, ...
Escin IB
T5S1389
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to a...
7-Ethoxyresorufin
T21507
7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
Kaempferol 3,7,4'-trimethyl ether
TN1817
Kaempferol 3,7,4'-trimethyl ether (Kaempferol 3,7,4'-trimethylether) shows selective cyctoxic activities against the nine tested cancer cell lines.
MSU-42011
T77499
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
Epibetulinic acid
T2S0765
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
Secologanic acid
TN1021
Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.
Mogroside IIA1
TN1934
Mogroside IIA1 (Mogroside II-A1) is isolated from the fruits of Siraitia grosvenorii. Mogroside IIA1 is a a nonsugar sweetener and sweeter than sucrose. Mogrosid...
Nitro blue tetrazolium chloride
T19032
Nitro blue tetrazolium chloride (NBT) is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 M). A well-known scavenger of...
Euscaphic acid
TN1134
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
Gardenin B
TN1675
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
Bendazol
T1322
Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.
Irisflorentin
T6S1665
1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-...
1 2 3 4 5 6 7
TargetMol