Home Tools
Log in
Cart

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2144 Resveratroloside 38963-95-0
Resveratroloside
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO producti...
TN1058 Pelargonidin chloride 134-04-3
Pelargonidin chloride
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T20232 Kazinol B 99624-27-8 98%
Kazinol B
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
T78738 HnNOS-IN-2 2700326-00-5 98%
hnNOS-IN-2
Compound 17, also known as hnNOS-IN-2, is an inhibitor of human neuronal nitric oxide synthase (hnNOS) that exhibits good metabolic stability. It is potentially ...
T78855 Anticancer agent 157 98%
Anticancer agent 157
Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It ...
T79473 Anti-inflammatory agent 46 2925586-96-3 98%
Anti-inflammatory agent 46
Anti-inflammatory agent 46 (compound 7h), exhibiting nitric oxide (NO) inhibitory properties, demonstrates a high affinity for iNOS through low binding energies ...
T79757 Meliadubin B 98%
Meliadubin B
Meliadubin B, a natural triterpenoid, effectively inhibits inflammatory responses by suppressing superoxide anion generation in human neutrophils (EC 50 of 5.54 ...
T79954 Kadsulignan H 144049-91-2 98%
Kadsulignan H
Kadsulignan H (compound 13), a lignan, exhibits inhibitory activity on nitric oxide (NO) production, presenting an IC50 value of 14.1 μM in BV-2 cells [1].
T79955 Schiarisanrin A 130252-41-4 98%
Schiarisanrin A
Schiarisanrin A (Kadsulignan J), a lignan, exhibits inhibitory activity on nitric oxide (NO) production, demonstrating an IC50 of 9.6 μM in BV-2 cells [1].
T79981 Nitric oxide production-IN-1 1013405-26-9 98%
Nitric oxide production-IN-1
Nitric oxide production-IN-1 (Compound 1) is an inhibitor of nitric oxide (NO) production extracted from Tupistra chinensis. It effectively suppresses NO synthes...
T80000 Multiflorin B 52657-01-9 98%
Multiflorin B
Multiflorin B (compound 5), a kaempferol glycoside, can be extracted from the root of Neocheiropteris palmatopedata. This compound demonstrates the ability to in...
T82251 GW274150 dihydrochloride 438542-17-7 98%
GW274150 dihydrochloride
GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependenc...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN2689 2',3,5,6',7-Pentahydroxyflavanone 80366-15-0 98%
2',3,5,6',7-Pentahydroxyflavanone
2',3,5,6',7-Pentahydroxyflavanone (3,5,7,2',6'-Pentahydroxyflavanone) is a natural product isolated from the roots of Scutellaria baicalensis.
TN3983 Ergosta-7,22-dien-3-one 32507-77-0 98%
Ergosta-7,22-dien-3-one
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory propertie...
T72638 INOS inhibitor-10 2918773-63-2 98%
iNOS inhibitor-10
iNOS Inhibitor-10, with an IC50 of 65 nM, exhibits antiproliferative effects on triple-negative breast cancer cells [1].
T73580 8A8 2766594-12-9 98%
8A8
8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferat...
TN1378 α-Viniferin 62218-13-7 98%
α-Viniferin
α-Viniferin belongs to a class of organic compounds, also known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin h...
T7206 2-Iminobiotin 13395-35-2 98%
2-Iminobiotin
2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal...
Resveratroloside
TN2144
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO producti...
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Kazinol B
T20232
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
hnNOS-IN-2
T78738
Compound 17, also known as hnNOS-IN-2, is an inhibitor of human neuronal nitric oxide synthase (hnNOS) that exhibits good metabolic stability. It is potentially ...
Anticancer agent 157
T78855
Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It ...
Anti-inflammatory agent 46
T79473
Anti-inflammatory agent 46 (compound 7h), exhibiting nitric oxide (NO) inhibitory properties, demonstrates a high affinity for iNOS through low binding energies ...
Meliadubin B
T79757
Meliadubin B, a natural triterpenoid, effectively inhibits inflammatory responses by suppressing superoxide anion generation in human neutrophils (EC 50 of 5.54 ...
Kadsulignan H
T79954
Kadsulignan H (compound 13), a lignan, exhibits inhibitory activity on nitric oxide (NO) production, presenting an IC50 value of 14.1 μM in BV-2 cells [1].
Schiarisanrin A
T79955
Schiarisanrin A (Kadsulignan J), a lignan, exhibits inhibitory activity on nitric oxide (NO) production, demonstrating an IC50 of 9.6 μM in BV-2 cells [1].
Nitric oxide production-IN-1
T79981
Nitric oxide production-IN-1 (Compound 1) is an inhibitor of nitric oxide (NO) production extracted from Tupistra chinensis. It effectively suppresses NO synthes...
Multiflorin B
T80000
Multiflorin B (compound 5), a kaempferol glycoside, can be extracted from the root of Neocheiropteris palmatopedata. This compound demonstrates the ability to in...
GW274150 dihydrochloride
T82251
GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependenc...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
2',3,5,6',7-Pentahydroxyflavanone
TN2689
2',3,5,6',7-Pentahydroxyflavanone (3,5,7,2',6'-Pentahydroxyflavanone) is a natural product isolated from the roots of Scutellaria baicalensis.
Ergosta-7,22-dien-3-one
TN3983
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory propertie...
iNOS inhibitor-10
T72638
iNOS Inhibitor-10, with an IC50 of 65 nM, exhibits antiproliferative effects on triple-negative breast cancer cells [1].
8A8
T73580
8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferat...
α-Viniferin
TN1378
α-Viniferin belongs to a class of organic compounds, also known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin h...
2-Iminobiotin
T7206
2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal...
1 2 3 4 5 6 7
TargetMol