NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat. No.	Product name	CAS No.	Purity
T12758	Ro 25-6981	169274-78-6	99.44%
T12758	Ro 25-6981 is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit with IC50s of 0.009 and 52 μM for cloned receptor subu...
T68599	Orphenadrine	83-98-7	99.38%
T68599	Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producin...
T5819	Rapastinel Trifluoroacetate	1435786-04-1	99.37%
T5819	Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
T27397	Gacyclidine	68134-81-6	99.35%
T27397	Gacyclidine (OTO311) is a small molecule N-methyl-D-aspartate (NMDA) receptor antagonist. Local injection of Gacyclidine in the cochlea inhibits salicylate-induc...
T23344	SDZ 220-040	174575-40-7	99.33%
T23344	SDZ 220-040 is a selective mammalian NMDA receptor antagonist that induces a partially gravity-free mode of root growth.
T27947L	LY339434 HCl		99.32%
T27947L	LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) rec...
T1324	O-Phospho-L-serine	407-41-0	99.31%
T1324	O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.
TQ0027	Transcrocetinate disodium	591230-99-8	99.22%
TQ0027	Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T1897	MDL-29951	130798-51-5	99.07%
T1897	MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T16797	RPR104632	154106-92-0	99.06%
T16797	RPR104632 is a novel and potent antagonist located at the NMDA glycine site with neuroprotective activity.
T3486	3-MATIDA	518357-51-2	99.05%
T3486	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4...
T22798	Gavestinel	153436-38-5	99.04%
T22798	Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA...
T72059	S1R agonist 2	150085-21-5	99.04%
T72059	S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
T0556	6-Methoxy-2-naphthoic acid	2471-70-7	99.03%
T0556	6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
T8394	D-Serine	312-84-5	99%
T8394	D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T6504	Flupirtine maleate	75507-68-5	98.99%
T6504	Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
T7870	TCN 201	852918-02-6	98.97%
T7870	TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T60237	L-Cysteine S-sulfate	1637-71-4	98.92%
T60237	L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for ...
T72662	NMDAR/TRPM4-IN-2	2243506-33-2	98.77%
T72662	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T8351	UBP551	89-35-0	98.77%
T8351	UBP551 is a potent and selective NMDA receptors modulator.