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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN6726 Methyl chlorogenate 29708-87-0 99.80%
methyl chlorogenate
Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
TN6730 Epoxyazadiradione 18385-59-6 99.8%
Epoxyazadiradione
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
TN1786 Isomerazin 1088-17-1 99.8%
Isomerazin
Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathw...
TN2232 Soyasaponin Ab 118194-13-1 99.79%
Soyasaponin Ab
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
T2921 Sinomenine hydrochloride 6080-33-7 99.79%
Sinomenine hydrochloride
Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.
T2872 Ginsenoside Re 52286-59-6 99.78%
Ginsenoside Re
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.
T0020 Sodium 4-aminosalicylate dihydrate 6018-19-5 99.78%
Sodium 4-aminosalicylate dihydrate
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA...
TQ0169 Inulicin 33627-41-7 99.77%
Inulicin
Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T2930 α-Lipoic Acid 62-46-4 99.76%
α-Lipoic Acid
α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hep...
T5S1097 Neferine 2292-16-2 99.75%
Neferine
1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Nefer...
T9656 AP-1/NF-κB activation inhibitor 1 188936-12-1 99.74%
AP-1/NF-κB activation inhibitor 1
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
T3892 Isoacteoside 61303-13-7 99.74%
Isoacteoside
Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
T6S1538 Neochlorogenic acid 906-33-2 99.73%
Neochlorogenic acid
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T5S1607 Morusin 62596-29-6 99.72%
Morusin
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuat...
TN2100 Pratensein 2284-31-3 99.72%
Pratensein
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
T25465 GS143 916232-21-8 99.72%
GS143
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and t...
TN1691 Glabrol 59870-65-4 99.72%
Glabrol
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T0429 Glucosamine 3416-24-8 99.72%
Glucosamine
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine ...
T0607 Dihydroartemisinin 71939-50-9 99.72%
Dihydroartemisinin
Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
T5687 WITHAFERIN A 5119-48-2 99.71%
WITHAFERIN A
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
methyl chlorogenate
TN6726
Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
Epoxyazadiradione
TN6730
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
Isomerazin
TN1786
Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathw...
Soyasaponin Ab
TN2232
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
Sinomenine hydrochloride
T2921
Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.
Ginsenoside Re
T2872
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.
Sodium 4-aminosalicylate dihydrate
T0020
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA...
Inulicin
TQ0169
Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
α-Lipoic Acid
T2930
α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hep...
Neferine
T5S1097
1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Nefer...
AP-1/NF-κB activation inhibitor 1
T9656
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...
Isoacteoside
T3892
Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
Neochlorogenic acid
T6S1538
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
Morusin
T5S1607
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuat...
Pratensein
TN2100
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
GS143
T25465
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and t...
Glabrol
TN1691
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
Glucosamine
T0429
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine ...
Dihydroartemisinin
T0607
Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
WITHAFERIN A
T5687
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
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TargetMol