NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
TN1126	Sakuranetin	2957-21-3	99%
TN1126	Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
T3402	20(S)-Ginsenoside Rg3	14197-60-5	98.99%
T3402	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
TN1637	Eurycomalactone	23062-24-0	98.98%
TN1637	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein...
TN1712	Gossypin	652-78-8	98.97%
TN1712	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the...
T8799	(E/Z)-IT-603	292168-90-2	98.97%
T8799	(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding...
T2775	Baicalin	21967-41-9	98.96%
T2775	Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV proper...
T3772	Maslinic acid	4373-41-5	98.93%
T3772	Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.
TN1077	Taraxerol	127-22-0	98.92%
TN1077	Taraxerol(Alnulin) is an anti-inflammatory and anticancer compound derived from dandelion.Taraxerol reduces acute inflammation and induces apoptosis by inhibitin...
TN2244	Sulfuretin	120-05-8	98.91%
TN2244	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its abili...
T13604	CDDO-dhTFEA	1191265-33-4	98.88%
T13604	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean art...
T39965	NF-κΒ activator 1	2387524-59-4	98.85%
T39965	NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferati...
TN2179	Saponarin	20310-89-8	98.84%
TN2179	Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T6561	Laquinimod	248281-84-7	98.84%
T6561	Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral the...
T2768	Saikosaponin A	20736-09-8	98.76%
T2768	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T67790	Biricodar dicitrate	174254-13-8	98.67%
T67790	Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.
TN2080	Pinoresinol	487-36-5	98.67%
TN2080	Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, ...
T4361	CBL0137 hydrochloride	1197397-89-9	98.59%
T4361	CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respecti...
TQ0198	Phorbol 12-myristate 13-acetate	16561-29-8	98.55%
TQ0198	Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13...
T1125	Shikonin	517-89-5	98.54%
T1125	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-...