NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T2777	Ginsenoside Rg1	22427-39-0	99.74%
T2777	Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spat...
T3892	Isoacteoside	61303-13-7	99.74%
T3892	Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
T6S1538	Neochlorogenic acid	906-33-2	99.73%
T6S1538	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T4518	Licochalcone D	144506-15-0	99.73%
T4518	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...
T5S1607	Morusin	62596-29-6	99.72%
T5S1607	1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuat...
TN2100	Pratensein	2284-31-3	99.72%
TN2100	Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
T77525	EN450	793719-01-4	99.72%
T77525	EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a...
T25465	GS143	916232-21-8	99.72%
T25465	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
T5S0993	Kurarinone	34981-26-5	99.72%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
TN1691	Glabrol	59870-65-4	99.72%
TN1691	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T0429	Glucosamine	3416-24-8	99.72%
T0429	Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine ...
T0607	Dihydroartemisinin	71939-50-9	99.72%
T0607	Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
T5687	WITHAFERIN A	5119-48-2	99.71%
T5687	WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
T28273L	OT-551 HCl	627085-15-8	99.71%
T28273L	OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular de...
T3862	Irigenin	548-76-5	99.71%
T3862	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain...
T61233	Penehyclidine hydrochloride	151937-76-7	99.7%
T61233	Penehyclidine hydrochloride (Penequinine hydrochloride) is an M1 and M3 antagonist and activates NF-κB in lung tissue. Penehyclidine hydrochloride inhibits the r...
TN1182	11-Keto-beta-boswellic acid	17019-92-0	99.7%
TN1182	11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
T2861	Tyrosol	501-94-0	99.69%
T2861	Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most abundan...
T3816	Velutin	25739-41-7	99.69%
T3816	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as ...
T10383	Asatone	38451-63-7	99.68%
T10383	Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK...