T1121 |
Podofilox
|
518-28-5
|
99.07%
|
|
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken int...
|
T1992 |
Mertansine
|
139504-50-0
|
99.06%
|
|
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through...
|
T60026 |
KIF18A-IN-2
|
2600559-20-2
|
99.05%
|
|
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.
|
T1034 |
Docetaxel
|
114977-28-5
|
99.03%
|
|
Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 ...
|
T0968 |
Paclitaxel
|
33069-62-4
|
98.91%
|
|
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest...
|
T1820 |
CK-636
|
442632-72-6
|
98.88%
|
|
CK-636 (CK-0944636), an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC5...
|
T1758 |
ABT-751
|
141430-65-1
|
98.84%
|
|
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
|
T0190 |
Vinorelbine
|
71486-22-1
|
98.84%
|
|
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the ar...
|
T19573 |
T807
|
1415379-56-4
|
98.83%
|
|
T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).
|
T0714 |
Oxfendazole
|
53716-50-0
|
98.81%
|
|
Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
|
T14348 |
Auristatin E
|
160800-57-7
|
98.81%
|
|
Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor a...
|
T1152 |
Albendazole
|
54965-21-8
|
98.76%
|
|
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
|
T1668 |
Vinblastine sulfate
|
143-67-9
|
98.75%
|
|
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
|
T6691 |
TAI-1
|
1334921-03-7
|
98.72%
|
|
TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
|
T2511 |
Plinabulin
|
714272-27-2
|
98.69%
|
|
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targe...
|
T60129 |
MT189
|
1885900-35-5
|
98.67%
|
|
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferat...
|
T60041 |
N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide
|
1383373-65-6
|
98.65%
|
|
N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM....
|
T6864 |
Ixabepilone
|
219989-84-1
|
98.60%
|
|
Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilizat...
|
T13807 |
OSIP-486823
|
200803-37-8
|
98.59%
|
|
OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.
|
T24977 |
4-Isopropoxybenzoic acid
|
13205-46-4
|
98.58%
|
|
4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.
|