T2610 |
BMS-599626
|
714971-09-2
|
98.79%
|
|
BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
|
T78209 |
Nedometinib
|
2252314-46-6
|
98%
|
|
Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutane...
|
T79048 |
MEK-IN-6 hydrate
|
2845153-35-5
|
98%
|
|
MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].
|
T79143 |
MS934
|
2756323-15-4
|
98%
|
|
MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM. It holds potential...
|
T80638 |
Glycinexylidide
|
18865-38-8
|
98%
|
|
Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting sodium channels with complex voltage...
|
T11993 |
MEK inhibitor
|
334951-92-7
|
98%
|
|
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
|
T10675 |
MEK-IN-1
|
870600-45-6
|
98%
|
|
MEK-IN-1 is a MEK inhibitor.
|
TN1953 |
Morusinol
|
62949-93-3
|
98%
|
|
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
T15193 |
EBI-1051
|
1801896-05-8
|
98%
|
|
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
|
TN4166 |
Griffipavixanthone
|
219649-95-3
|
98%
|
|
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
|
TN5201 |
Uncarinic acid E
|
277751-61-8
|
98%
|
|
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
|
TN3711 |
Corylifol C
|
775351-91-2
|
98%
|
|
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
|
TN3397 |
Alpinumisoflavone
|
34086-50-5
|
98%
|
|
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
|
T13782 |
MS432
|
T13782
|
98%
|
|
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
|
T14055 |
5Z-7-Oxozeaenol
|
253863-19-3
|
98%
|
|
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
|
T22677 |
Cobimetinib racemate
|
934662-91-6
|
98%
|
|
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated prote...
|
T21332 |
U0126
|
109511-58-2
|
98%
|
|
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
|
TN1462 |
Cajanin
|
32884-36-9
|
98%
|
|
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
|
T3623 |
Cobimetinib
|
934660-93-2
|
99.98%
|
|
Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits t...
|