MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Cat. No.	Product name	CAS No.	Purity
T11438	GNE-1858	2680616-96-8	98.70%
T11438	GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutan...
T6760	APS-2-79 hydrochloride	2002381-31-7	98.64%
T6760	APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the co...
T3707	GNE-3511	1496581-76-0	98.64%
T3707	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T5S1895	Norisoboldine	23599-69-1	98.64%
T5S1895	1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as we...
T4264	Takinib	1111556-37-6	98.47%
T4264	Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
T12237	NMS-P715	1202055-32-0	98.41%
T12237	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T11961	MBM-55S	2083624-07-9	98.38%
T11961	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
T26193	SKLB-163	1255099-06-9	98.31%
T26193	SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
T10865L	Cot inhibitor-1 hydrochloride	T10865L	98.26%
T10865L	Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
T9034	MK2-IN-3	724711-21-1	98.14%
T9034	MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be ...
T62209	HS-276	2767422-72-8	98.07%
T62209	HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22...
T8911	Methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate	517870-17-6	97.95%
T8911	methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
T5643	NG25	1315355-93-1	97.59%
T5643	NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
T60012	HS-243	848249-10-5	97.34%
T60012	HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
T40350	HPK1-IN-4	2739844-28-9	97.2%
T40350	HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
T3101	NQDI-1	175026-96-7	97.19%
T3101	NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T9880	ZINC05007751	591239-68-8	97.12%
T9880	ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
T63119	NF-κB/MAPK-IN-1	2413940-56-2	97.03%
T63119	NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition ...
T36680	SM1-71	2088179-99-9	96%
T36680	SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...
TN4114	Gardenin A	21187-73-5	95.15%
TN4114	Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.