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MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 189689-32-5 98%
6,4'-Dihydroxy-7-methoxyflavanone
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
TN4194 Heliangin 13323-48-3 98%
Heliangin
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells...
T14055 5Z-7-Oxozeaenol 253863-19-3 98%
5Z-7-Oxozeaenol
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
TN4315 Isonardosinone 27062-01-7 98%
Isonardosinone
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
TL0017 Aristolactam AIIIa 97399-91-2 98%
Aristolactam AIIIa
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
TN1660 Ganoderic acid C1 95311-97-0 98%
Ganoderic acid C1
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T28141 Nek2-IN-5 1507367-00-1 98%
Nek2-IN-5
Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).
TN4785 Picrasidine I 100234-59-1 98%
Picrasidine I
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene ...
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
T11960 MBM-55 2083622-09-5 99.98%
MBM-55
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
T60011 HS220 1570374-32-1 99.98%
HS220
HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.
T3603 Sodium lauryl sulfoacetate 1847-58-1 99.83%
Sodium lauryl sulfoacetate
Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
TN1441 Beta-Tocopherol 148-03-8 99.8%
Beta-Tocopherol
Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
T67942 Antimicrobial agent-21 724746-07-0 99.72%
Antimicrobial agent-21
Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of c...
T13099 TC ASK 10 1005775-56-3 99.71%
TC ASK 10
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
T38796L MBP MAPK Substrate acetate 99.71%
MBP MAPK Substrate acetate
MBP MAPK Substrate acetate can be used as an exogenous substrate for MAPK.
T14988 CMPD1 41179-33-3 99.67%
CMPD1
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
T4442 MK2-IN-1 hydrochloride 1314118-94-9 99.67%
MK2-IN-1 hydrochloride
MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 ...
T2382 Vemurafenib 918504-65-1 99.65%
Vemurafenib
Vemurafenib (RG7204) (PLX4032) is a novel and potent B-Raf (V600E) inhibitor (IC50: 31 nM).
T5483 DMX-5804 2306178-56-1 99.63%
DMX-5804
DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice....
6,4'-Dihydroxy-7-methoxyflavanone
TN3144
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
Heliangin
TN4194
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells...
5Z-7-Oxozeaenol
T14055
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
Isonardosinone
TN4315
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
Aristolactam AIIIa
TL0017
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
Ganoderic acid C1
TN1660
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
Nek2-IN-5
T28141
Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).
Picrasidine I
TN4785
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene ...
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
MBM-55
T11960
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
HS220
T60011
HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.
Sodium lauryl sulfoacetate
T3603
Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
Beta-Tocopherol
TN1441
Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
Antimicrobial agent-21
T67942
Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of c...
TC ASK 10
T13099
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
MBP MAPK Substrate acetate
T38796L
MBP MAPK Substrate acetate can be used as an exogenous substrate for MAPK.
CMPD1
T14988
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
MK2-IN-1 hydrochloride
T4442
MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 ...
Vemurafenib
T2382
Vemurafenib (RG7204) (PLX4032) is a novel and potent B-Raf (V600E) inhibitor (IC50: 31 nM).
DMX-5804
T5483
DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice....
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TargetMol