Lipase

Lipase refers to a class of enzymes that catalyze the hydrolysis of fats. Some lipases display a broad substrate scope including esters of cholesterol, phospholipids, and of lipid-soluble vitamins, and sphingomyelinases; however, these are usually treated separately from "conventional" lipases. Unlike esterases, which function in water, lipases "are activated only when adsorbed to an oil-water interface". Lipases perform essential roles in the digestion, transport and processing of dietary lipids in most organisms.

Cat. No.	Product name	CAS No.	Purity
T11939	MAGL-IN-1	2324160-91-8	98%
T11939	MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T16496	PF-06795071	2075629-81-9	98%
T16496	PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T1875	Atglistatin	1469924-27-3	99.81%
T1875	Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the...
T2338	JZL195	1210004-12-8	99.78%
T2338	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2249	XEN445	1515856-92-4	99.75%
T2249	XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
T9374	AA38-3	65815-76-1	99.70%
T9374	AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
T2966	Beta-Sitosterol	83-46-5	99.68%
T2966	Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Be...
T3591	URB602	565460-15-3	99.64%
T3591	URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
T73499	NG-497	2598242-66-9	99.56%
T73499	NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain ...
T27703	JZP-361	1680193-80-9	99.41%
T27703	JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 disp...
T15614	JJKK 048	1515855-97-6	99.22%
T15614	JJKK 048 is a potent and selective MAGL inhibitor.
T15632	JW 642	1416133-89-5	99.13%
T15632	JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
T15635	JZP-430	1672691-74-5	98.31%
T15635	JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
T41160	Lalistat 2	1234569-09-5	98.30%
T41160	Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein...
T17260	WWL70	947669-91-2	98.25%
T17260	WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T28165	NF-1819	1881244-28-5	98.21%
T28165	NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhi...
T5737	Euphol	514-47-6	98%
T5737	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
T5815	MJN110	1438416-21-7	98%
T5815	MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing...
T6554	JZL 184	1101854-58-3	97.6%
T6554	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T11199	Endothelial lipase inhibitor-1	1466427-02-0	97.38%
T11199	Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.