LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).

Cat. No.	Product name	CAS No.	Purity
T78091	(S)-FTY720-phosphonate	1142015-10-8	98%
T78091	FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury.
T78160	SLB1122168 formic		98%
T78160	SLB1122168 is a potent inhibitor of Spns2-mediated sphingosine-1-phosphate (S1P) release, exhibiting an IC50 value of 94 nM [1].
T79816	S1P1 agonist 6	2433782-42-2	98%
T79816	Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive ...
T79817	S1P1 agonist 6 hemicalcium	2941310-03-6	98%
T79817	Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppr...
T81114	Spns2-IN-1		98%
T81114	Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immune re...
T17237	VPC 23019	449173-19-7	98%
T17237	VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T4031	S1p receptor agonist 1	1514888-56-2	99.94%
T4031	S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
T8840	PF-543 hydrochloride	1706522-79-3	99.92%
T8840	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isofo...
T10293	AM095 free acid	1228690-36-5	99.9%
T10293	AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
T15031	CYM50260	1355026-60-6	99.88%
T15031	CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R a...
T7939	Fingolimod	162359-55-9	99.76%
T7939	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T6923	Ozanimod	1306760-87-1	99.74%
T6923	Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative...
T17183	TY-52156	934369-14-9	99.73%
T17183	TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T10305	Amiselimod hydrochloride	942398-84-7	99.68%
T10305	Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T2171	SEW2871	256414-75-2	99.62%
T2171	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies r...
T10385	ASP-4058	952565-91-2	99.51%
T10385	ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
T4278	AM966	1228690-19-4	99.49%
T4278	AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
T22834	H2L 5765834	420841-84-5	99.47%
T22834	H2L 5765834 is a lysophosphatidic acid receptors antagonist
T7832	Ibrolipim	133208-93-2	99.47%
T7832	Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
T12821	S1PR1 modulator 1	2328109-05-1	99.44%
T12821	S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.