TQ0089 |
Juglanin
|
5041-67-8
|
99.33%
|
|
Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.
|
T4S1962 |
Beta-Asarone
|
5273-86-9
|
99.32%
|
|
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing RO...
|
TN1918 |
Medicarpin
|
32383-76-9
|
99.32%
|
|
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
|
TN7121 |
D-Epigalbacin
|
84709-25-1
|
99.25%
|
|
d-Epigalbacin ((-)-Zuonin A) is a naturally occurring lignin. d-Epigalbacin is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for J...
|
T2343 |
AS601245
|
345987-15-7
|
99.02%
|
|
AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.
|
T7677 |
JNK Inhibitor VIII
|
894804-07-0
|
99.01%
|
|
JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, resp...
|
T14895 |
Tanzisertib
|
899805-25-5
|
98.95%
|
|
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.
|
T3S1641 |
Esculentoside H
|
66656-92-6
|
98.9%
|
|
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
|
T5S2283 |
Sesamolin
|
526-07-8
|
98.89%
|
|
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
|
T2973 |
Astragaloside IV
|
84687-43-4
|
98.85%
|
|
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metall...
|
T39823L |
Apelin-12 acetate
|
T39823L
|
98.82%
|
|
Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-r...
|
T6677 |
Sophocarpine
|
6483-15-4
|
98.67%
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
T7008 |
Vacquinol-1
|
5428-80-8
|
98.67%
|
|
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
|
TMA0507 |
Tomatidine
|
77-59-8
|
98.38%
|
|
Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C....
|
T26193 |
SKLB-163
|
1255099-06-9
|
98.31%
|
|
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
|
TN2290 |
Uvaol
|
545-46-0
|
98.27%
|
|
Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.
|
T9138 |
Indirubin-3′-oxime
|
667463-82-3
|
98.26%
|
|
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
|
T2668 |
JNK-IN-8
|
1410880-22-6
|
98.25%
|
|
JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of M...
|
T6S1371 |
Isovitexin
|
38953-85-4
|
98.24%
|
|
1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase i...
|
T3S0006 |
(E)-Ferulic acid methyl ester
|
22329-76-6
|
98.22%
|
|
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
|