T3398 |
Icaritin
|
118525-40-9
|
98.50%
|
|
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
|
T4227 |
SB1317 hydrochloride (1204918-72-8(free base))
|
T4227
|
98.39%
|
|
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).
|
T35899 |
JAK1-IN-8
|
1973485-18-5
|
98.36%
|
|
JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
|
TQ0196 |
Cucurbitacin I
|
2222-07-3
|
98.2%
|
|
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
|
T2012 |
Oclacitinib
|
1208319-26-9
|
98.12%
|
|
Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 n...
|
T1929 |
Filgotinib
|
1206161-97-8
|
98.03%
|
|
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
|
T2045 |
JANEX-1
|
202475-60-3
|
98.03%
|
|
JANEX-1 (Jak3 inhibitor I) is a cell-permeable, reversible, effective, ATP-competitive, and selective inhibitor of JAK3 (IC50: 78 μM); little inhibitory against ...
|
T7123 |
AMG-47a
|
882663-88-9
|
98%
|
|
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the lev...
|
T3673 |
Mollugin
|
55481-88-4
|
98%
|
|
Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a ...
|
T6020 |
Pacritinib
|
937272-79-2
|
98%
|
|
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).
|
T5S1897 |
Linderalactone
|
728-61-0
|
97.86%
|
|
1. Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.
|
T39113L |
Povorcitinib phosphate
|
1637677-33-8
|
97.71%
|
|
Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.
|
T5S0167 |
Atractylenolide I
|
73069-13-3
|
97.55%
|
|
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
|
T3069 |
AZD-1480
|
935666-88-9
|
97.5%
|
|
AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been ...
|
T5492 |
JAK3-IN-6
|
1443235-95-7
|
97.34%
|
|
JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM
|
T2378 |
RGB-286638 free base
|
784210-88-4
|
97.29%
|
|
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
|
T6838 |
FLLL32
|
1226895-15-3
|
96.39%
|
|
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
|
T6266 |
PP2
|
172889-27-9
|
95.65%
|
|
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
|
T20743 |
TG-46
|
936091-15-5
|
100%
|
|
TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.
|
T4672 |
Brevilin A
|
16503-32-5
|
100%
|
|
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor a...
|