T13336 |
VTP50469
|
2169916-18-9
|
98.31%
|
|
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
|
T6900 |
MS023
|
1831110-54-3
|
98.31%
|
|
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, r...
|
T13780 |
MS1943
|
2225938-17-8
|
98.26%
|
|
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
|
T7194 |
CM-272
|
1846570-31-7
|
98.21%
|
|
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
|
T12428L |
PF-06726304
|
1616287-82-1
|
98.19%
|
|
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH...
|
T12344L1 |
OTS186935 FA
|
|
98.16%
|
|
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
|
T7305 |
JQEZ5
|
1913252-04-6
|
98.14%
|
|
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
|
T16886 |
Sinefungin
|
58944-73-3
|
98.12%
|
|
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multipl...
|
T67697 |
WDR5-47
|
1422389-91-0
|
98.08%
|
|
WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.
|
T27133 |
DCLX069
|
792946-69-1
|
98.06%
|
|
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
|
T40199 |
Tulmimetostat
|
2567686-02-4
|
98.04%
|
|
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced sol...
|
T1868 |
JIB-04
|
199596-05-9
|
98.02%
|
|
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
|
T7157 |
XY1
|
1624117-53-8
|
98%
|
|
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
|
T7378 |
BRD9539
|
1374601-41-8
|
98%
|
|
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
|
T4378 |
MS049
|
1502816-23-0
|
98%
|
|
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
|
T72979 |
LEM-14-1189
|
2987501-17-5
|
97.98%
|
|
Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with ...
|
TQ0263 |
EPZ031686
|
1808011-22-4
|
97.91%
|
|
EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
|
T12430 |
PF-06821497
|
1844849-10-0
|
97.88%
|
|
PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.
|
T10205 |
A-395
|
2089148-72-9
|
97.82%
|
|
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC5...
|
T8838 |
CCI-007
|
939228-52-1
|
97.81%
|
|
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
|