Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T2379	UNC1215	1415800-43-9	98.87%
T2379	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
T9681	MAK-683 hydrochloride	2170606-94-5	98.87%
T9681	MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50s of 59, 26, 89 nM in EED Alphascreen binding, ELISA and LC-MS ...
T67883	EZH2-IN-15	2098545-98-1	98.85%
T67883	EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls th...
T8381	Amodiaquine	86-42-0	98.84%
T8381	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
T15767	LLY-283	2040291-27-6	98.79%
T15767	LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, a...
T13279L	Valemetostat	1809336-39-7	98.77%
T13279L	Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor.
T4166	UNC0642	1481677-78-4	98.75%
T4166	UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
T14841	BVT948	39674-97-0	98.70%
T14841	BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
T12943	SNDX-5613	2169919-21-3	98.7%
T12943	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearra...
T2097	C-7280948	587850-67-7	98.68%
T2097	C-7280948 is a PRMT1 inhibitor.
T64043	EZH2-IN-13	1403255-41-3	98.68%
T64043	EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.
T23284	Ryuvidine	265312-55-8	98.6%
T23284	Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and ...
T3624	A-366	1527503-11-2	98.53%
T3624	A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
TQ0100	AZ505	1035227-43-0	98.48%
TQ0100	AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
T9575	MRTX9768	2629314-68-5	98.48%
T9575	MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
T8201	Gambogenic acid	173932-75-7	98.36%
T8201	Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
T6360	3-deazaneplanocin A HCl	120964-45-6	98.34%
T6360	3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
T60194	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide	2238820-26-1	98.33%
T60194	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and se...
T13336	VTP50469	2169916-18-9	98.31%
T13336	VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T6900	MS023	1831110-54-3	98.31%
T6900	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, r...