T10882 |
CPUY074020
|
902279-44-1
|
99.07%
|
|
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
|
T28996 |
TP-064
|
2080306-20-1
|
99.07%
|
|
TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold sel...
|
T9742 |
SETDB1-TTD-IN-1
|
2755823-12-0
|
99.05%
|
|
SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
|
T17002 |
Tazemetostat hydrobromide
|
1467052-75-0
|
99.03%
|
|
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repre...
|
T15194 |
EBI-2511
|
2098546-05-3
|
99.01%
|
|
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
|
T3081 |
EPZ004777
|
1338466-77-5
|
98.99%
|
|
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
|
T1959 |
BIX-01294 trihydrochloride
|
1392399-03-9
|
98.98%
|
|
BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.
|
T63351L |
MS8511 HCl
|
|
98.90%
|
|
MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer ...
|
T9969 |
EZM0414
|
2411748-50-8
|
98.9%
|
|
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay. EZM04...
|
T9399 |
Menin-MLL inhibitor 20
|
2448173-47-3
|
98.89%
|
|
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities (WO2020142557A1, compound 6).
|
T2379 |
UNC1215
|
1415800-43-9
|
98.87%
|
|
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
|
T9681 |
MAK-683 hydrochloride
|
2170606-94-5
|
98.87%
|
|
MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED) (patent US20160176882 A1, compound example 2). MAK683 exhibits IC50s of 59, 26, 89 n...
|
T67883 |
EZH2-IN-15
|
2098545-98-1
|
98.85%
|
|
EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls th...
|
T8381 |
Amodiaquine
|
86-42-0
|
98.84%
|
|
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
|
T15767 |
LLY-283
|
2040291-27-6
|
98.79%
|
|
LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, a...
|
T13279L |
Valemetostat
|
1809336-39-7
|
98.77%
|
|
Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor.
|
T6333 |
MM-102
|
1417329-24-8
|
98.77%
|
|
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM.
|
T2354 |
UNC 0631
|
1320288-19-4
|
98.76%
|
|
UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
|
T4166 |
UNC0642
|
1481677-78-4
|
98.75%
|
|
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
|
T14841 |
BVT948
|
39674-97-0
|
98.70%
|
|
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
|