Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T3458	EED226	2083627-02-3	99.66%
T3458	EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
T15624	JNJ-64619178	2086772-26-9	99.63%
T15624	JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity ...
T10840L	CM-579	1846570-40-8	99.62%
T10840L	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T11925	M‑89	2363165-42-6	99.58%
T11925	M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin bindi...
T28112	MS0124	1197196-63-6	99.56%
T28112	MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
T1775	GSK503	1346572-63-1	99.54%
T1775	GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.
T3257	UNC0638	1255580-76-7	99.53%
T3257	UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ep...
T61338	MS023 dihydrochloride	1992047-64-9	99.52%
T61338	MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitum...
T6810	CPI-360	1802175-06-9	99.52%
T6810	CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
T3057	UNC1999	1431612-23-5	99.49%
T3057	UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).
T4021	UNC3866	1872382-47-2	99.47%
T4021	UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
T9329	BRD0639	2760881-74-9	99.46%
T9329	BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM),...
T1841	UNC0379	1620401-82-2	99.45%
T1841	UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
T70087	EPZ032597	1887193-58-9	99.41%
T70087	EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and can be used to prevent and treat pancreatic cancer...
T21767	MS37452	423748-02-1	99.39%
T21767	MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
T36631	BAY-6035	2247890-13-5	99.39%
T36631	BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
T60002	DC-S239	303141-21-1	99.36%
T60002	DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
T6853	GSK591	1616391-87-7	99.35%
T6853	GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).
T4583	PFI-2 hydrochloride	1627607-87-7	99.31%
T4583	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 5...
T8768	MM-102 TFA	1883545-52-5	99.3%
T8768	MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed l...