Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T3278	Piribedil	3605-01-4	99.91%
T3278	Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
T6857	HLCL-61 hydrochloride	1158279-20-9	99.91%
T6857	HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
T6059	GSK343	1346704-33-3	99.9%
T6059	GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against othe...
T2352	AMI-1	20324-87-2	99.9%
T2352	AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).
T0381	Amodiaquine dihydrochloride dihydrate	6398-98-7	99.9%
T0381	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with ant...
T7089	SGC2085	1821908-48-8	99.86%
T7089	SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).
T29231	ZLD1039	1826865-46-6	99.82%
T29231	ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhi...
T1923	BRD4770	1374601-40-7	99.82%
T1923	BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.
T3082	SGC0946	1561178-17-3	99.82%
T3082	SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.
T9584	UNC6934	2561494-77-5	99.81%
T9584	UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
T2435	EPZ011989	1598383-40-4	99.81%
T2435	EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold sele...
T40233	(Iso)-MS4322	2601727-80-2	99.76%
T40233	(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively ...
T3084	SGC707	1687736-54-4	99.75%
T3084	SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
T6916	OICR-9429	1801787-56-3	99.74%
T6916	OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemi...
T1788	Tazemetostat	1403254-99-8	99.72%
T1788	Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits an...
T73185	PRMT6-IN-3	2890765-10-1	99.71%
T73185	PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.
T2079	GSK126	1346574-57-9	99.67%
T2079	GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).
T5322	BCI-121	432529-82-3	99.67%
T5322	BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.
T11500L	GSK3368715 dihydrochloride	1628925-77-8	99.66%
T11500L	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with antica...
T62957	MRK-740	2387510-80-5	99.66%
T62957	MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K...