Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T77787	MS023 trihydrochloride	2108631-19-0	99.81%
T77787	MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity...
T4334	EPZ020411 2HCl (1700663-41-7(free base))	T4334	99.2%
T4334	EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T4314	EPZ020411	1700663-41-7
T4314	EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
T1987	PFI-2	1627676-59-8
T1987	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T3081L	EPZ004777 hydrochloride	1380316-03-9
T3081L	EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T78152	PRMT5-IN-25	2691869-82-4	98%
T78152	PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1]....
T78172	PRMT5-IN-29	2242788-69-6	98%
T78172	PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].
T78929	Anticancer agent 126		98%
T78929	Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYC t...
T79007	CARM1-IN-3	912970-67-3	98%
T79007	CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for C...
T79035	PRMT5-IN-28	2242753-66-6	98%
T79035	PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes in...
T79120	WM-586	2894832-05-2	98%
T79120	WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding. It selectively reduces the interaction between WDR5 and MYC with an IC50 value of 101 n...
T79200	BBDDL2059	2691174-27-1	98%
T79200	BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant. It demonstrates potency in inhibiting lym...
T79249	Antitumor agent-101	2848632-52-8	98%
T79249	Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM for GL...
T79274	PRMT5-IN-31		98%
T79274	PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishi...
T79275	Antiproliferative agent-25		98%
T79275	Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM. It elevates hnRNP E1 protein levels and forms hydrogen bo...
T79355	PRMT4-IN-3		98%
T79355	PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37 nM...
T79614	EML734		98%
T79614	EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.
T79615	MS9715		98%
T79615	MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligase ...
T79616	UNC7096		98%
T79616	UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1]...
T79617	NSD2-IN-4		98%
T79617	NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].