Histone Demethylase

Histone demethylase proteins have a variety of domains that serve different functions. These functions include binding to the histone (or sometimes the DNA on the nucleosome), recognizing the correct methylated amino acid substrate and catalyzing the reaction, and binding cofactors. Cofactors include: alpha-keto glutarate (JmjC-domain containing demethylases), CoREST (LSD), FAD, Fe (II) or NOG (N-oxalylglycine).

Cat. No.	Product name	CAS No.	Purity
T11756	Kgp-IN-1	2097865-36-4	98%
T11756	Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.
T13745	KF21213	155271-17-3	98%
T13745	KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.
T11880	LSD1-IN-5	2035912-55-9	98%
T11880	LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific de...
T16435	PBIT	2514-30-9	99.95%
T16435	PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specif...
T13055	T-3775440 hydrochloride	1422535-52-1	99.94%
T13055	T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
T9094	JMJD7-IN-1	311316-96-8	99.9%
T9094	JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activ...
T3719	Daminozide	1596-84-5	99.88%
T3719	Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
T67738	3-pyridine toxoflavin	32502-20-8	99.83%
T67738	3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.
T15650	KDM5A-IN-1	1905481-36-8	99.8%
T15650	KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 va...
T4100	AS8351	796-42-9	99.72%
T4100	AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-101...
T6847	GSK-J1	1373422-53-7	99.67%
T6847	GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >...
T11748	KDM2A/7A-IN-1	2169272-46-0	99.59%
T11748	KDM2A/7A-IN-1 is a cell-permeable and selective inhibitor of the histone lysine demethylase KDM2A/7A with potential antitumor activity for the study of duodenal ...
T17211	Vafidemstat	1357362-02-7	99.53%
T17211	Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neuro...
T67871	LSD1-IN-24	4734-59-2	99.53%
T67871	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, ...
T9243	PFI-90	53995-62-3	99.5%
T9243	PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myog...
T10983L	DDP-38003 dihydrochloride	1831167-98-6	99.5%
T10983L	DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).
T2304	SP2509	1423715-09-6	99.49%
T2304	SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).
T6922	ORY1001	1431326-61-2	99.4%
T6922	ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminox...
T6545	IOX1	5852-78-8	99.38%
T6545	IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respec...
T67781	SD49-7	54009-54-0	99.36%
T67781	SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.