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Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T23095 NU 9056 1450644-28-6 95.36%
NU 9056
NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein a...
T78815 MOZ-IN-3 98%
MOZ-IN-3
MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cel...
T79086 MC4171 98%
MC4171
MC4171 (compound 34), a selective KAT8 inhibitor (IC50=8.1 µM), demonstrates moderate antiproliferative activity at micromolar concentrations in various cancer c...
T79131 KAT modulator-1 1314006-43-3 98%
KAT modulator-1
KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].
T4362 WM-8014 2055397-18-5 99.95%
WM-8014
WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
T12098 MOZ-IN-2 2055397-88-9 99.89%
MOZ-IN-2
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
T0065 Acetaminophen 103-90-2 99.88%
Acetaminophen
Analgesic antipyretic derivative of acetanilide. Acetaminophen (APAP) has weak anti-inflammatory properties and is used as a common analgesic, but may cause live...
T60558 NSC 694623 907957-34-0 99.87%
NSC 694623
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows...
T7856 Naphthol AS-E 92-78-4 99.85%
Naphthol AS-E
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T6908 NSC 228155 113104-25-9 99.84%
NSC 228155
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T3499 Remodelin 949912-58-7 99.78%
Remodelin
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
TN1150 Procyanidin B3 23567-23-9 99.71%
Procyanidin B3
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
T8344 CPTH2 357649-93-5 99.5%
CPTH2
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
T5468 YF-2 1311423-89-8 99.19%
YF-2
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T6584 MG 149 1243583-85-8 99.1%
MG 149
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T3969 I-CBP112 1640282-31-0 99.1%
I-CBP112
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T1516 Curcumin 458-37-7 98.98%
Curcumin
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
T6389 Anacardic Acid 16611-84-0 98.84%
Anacardic Acid
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial...
T6668 SGC-CBP30 1613695-14-9 98.64%
SGC-CBP30
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T11807 L002 321695-57-2 98.59%
L002
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
NU 9056
T23095
NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein a...
MOZ-IN-3
T78815
MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cel...
MC4171
T79086
MC4171 (compound 34), a selective KAT8 inhibitor (IC50=8.1 µM), demonstrates moderate antiproliferative activity at micromolar concentrations in various cancer c...
KAT modulator-1
T79131
KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].
WM-8014
T4362
WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
MOZ-IN-2
T12098
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
Acetaminophen
T0065
Analgesic antipyretic derivative of acetanilide. Acetaminophen (APAP) has weak anti-inflammatory properties and is used as a common analgesic, but may cause live...
NSC 694623
T60558
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows...
Naphthol AS-E
T7856
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
NSC 228155
T6908
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
Remodelin
T3499
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
Procyanidin B3
TN1150
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
CPTH2
T8344
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
YF-2
T5468
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
MG 149
T6584
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
I-CBP112
T3969
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
Curcumin
T1516
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
Anacardic Acid
T6389
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial...
SGC-CBP30
T6668
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
L002
T11807
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
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