Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.

Cat. No.	Product name	CAS No.	Purity
T2590	Vismodegib	879085-55-9	99.99%
T2590	Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T1926	Sonidegib	956697-53-3	99.97%
T1926	Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T3588	JK184	315703-52-7	99.89%
T3588	JK184 is a potent Hedgehog (Hh) pathway inhibitor.
T15370	GANT 58	64048-12-0	99.88%
T15370	GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
T24754	Hh-Ag1.5	612542-14-0	99.87%
T24754	Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 n...
T2450	SANT-1	304909-07-7	99.84%
T2450	SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T12797	RU-SKI 43	1043797-53-0	99.78%
T12797	RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compoun...
T1543	Naftifine hydrochloride	65473-14-5	99.76%
T1543	Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact...
T0465	Ellagic acid	476-66-4	99.76%
T0465	Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the ...
T26296	Triparanol	78-41-1	99.73%
T26296	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1,...
T2299	BMS-833923	1059734-66-5	99.61%
T2299	BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T3363	Jervine	469-59-0	99.57%
T3363	The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits ...
T35559	SAG 21k	946002-48-8	99.51%
T35559	SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.
T15183	Dynarrestin	2222768-84-3	99.49%
T15183	Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. ...
T23027	MRT-10	330829-30-6	99.47%
T23027	MRT-10 is a Smoothened (Smo) receptor antagonist.
T6891	MK-4101	935273-79-3	98.91%
T6891	MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in ...
T1779	SAG	912545-86-9	98.88%
T1779	SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo he...
T21325	TAK-441	1186231-83-3	98.79%
T21325	TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expr...
T14188	ALLO-2	1357350-60-7	98.67%
T14188	ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T63429	SMO-IN-2	1822355-27-0	98.64%
T63429	SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medull...