HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T0194	Chloroquine phosphate	50-63-5	99.64%
T0194	Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of...
T4557	Amylmetacresol	1300-94-3	99.64%
T4557	Amylmetacresol (5-Methyl-2-Pentylphenol) is used in the treatment of sore throat or 'acute sore throat', pharyngitis, tonsillitis and laryngitis. As well as in t...
T0781	Dimercaprol	59-52-9	99.64%
T0781	Dimercaprol (Dicaptol) is an anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisit...
T6246	Cobicistat	1004316-88-4	99.62%
T6246	Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, ...
T9039	HIV-1 Nef-IN-1	13728-56-8	99.62%
T9039	HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM).
TN2158	Robinetin	490-31-3	99.61%
TN2158	Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with hig...
T1595	Nevirapine	129618-40-2	99.6%
T1595	Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral...
T3683	Lithospermic acid	28831-65-4	99.6%
T3683	lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
T8238	Fosamprenavir Calcium Salt	226700-81-8	99.59%
T8238	Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fo...
T5782	Bevirimat	174022-42-5	99.58%
T5782	Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
T7499	TAK-779	229005-80-5	99.58%
T7499	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T2551	Etravirine	269055-15-4	99.56%
T2551	Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutation...
T0153	Oltipraz	64224-21-1	99.56%
T0153	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
T0682	Lamivudine	134678-17-4	99.56%
T0682	Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to...
T10603	BRD-6929	849234-64-6	99.54%
T10603	BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1....
T3060	Fasudil hydrochloride	105628-07-7	99.54%
T3060	Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T0033	Miltefosine	58066-85-6	99.51%
T0033	Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medic...
T7779	Nelfinavir	159989-64-7	99.5%
T7779	Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticanc...
T7064	Valproic Acid	99-66-1	99.49%
T7064	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be u...
T3323	Ursonic Acid	6246-46-4	99.48%
T3323	Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Pro...