HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T7212	Delavirdine mesylate	147221-93-0	99.75%
T7212	Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T0131	Cepharanthine	481-49-2	99.74%
T0131	Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and ...
T3199	PTACH	848354-66-5	99.74%
T3199	PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
T30047	Ancriviroc	370893-06-4	99.74%
T30047	Ancriviroc(CHEMBL336672), an imidoxime with strong antiretroviral activity, is a potent CCR5 inhibitor that can be used to study HIV.
T2329	Dolutegravir sodium	1051375-19-9	99.74%
T2329	Dolutegravir sodium (GSK-1349572A) salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mut...
T2332	Elvitegravir	697761-98-1	99.73%
T2332	Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhi...
T1284	Megestrol acetate	595-33-5	99.72%
T1284	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic pr...
T30527	BMS-488043	452296-83-2	99.72%
T30527	BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+) l...
T6098	Cabotegravir	1051375-10-0	99.71%
T6098	Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC...
T67804	KM-023	1097628-00-6	99.70%
T67804	KM-023 is a new second-generation non-nucleoside reverse transcriptase inhibitor for the study of human immunodeficiency virus (HIV) type 1 infection.
T2324	Darunavir	206361-99-1	99.69%
T2324	Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when ...
T2556	Nandrolone decanoate	360-70-3	99.68%
T2556	Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anaboli...
T27260	Emivirine	149950-60-7	99.68%
T27260	Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
T0753	Salicylanilide	87-17-2	99.68%
T0753	Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.
TP1348	FC131 TFA (606968-52-9 free base)	842166-42-1	99.67%
TP1348	FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv act...
T0100	Atazanavir sulfate	229975-97-7	99.67%
T0100	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with ...
T11074	Dolutegravir intermediate-1	1335210-23-5	99.67%
T11074	Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir in...
T67797	DDG-39	119555-47-4	99.66%
T67797	DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The a...
T4578	Tipranavir	174484-41-4	99.66%
T4578	Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activit...
TN4673	(+)-Nortrachelogenin	61521-74-2	99.64%
TN4673	(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.