HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T11189	Emtricitabine S-oxide	152128-77-3	98%
T11189	Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine su...
T10111	3-Deazaadenosine hydrochloride	86583-19-9	99.99%
T10111	3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 µM). It has anti-inflammatory, anti-proliferative, and anti-HIV activ...
T0828	Bromhexine hydrochloride	611-75-6	99.98%
T0828	Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
T3172	Trovirdine	149488-17-5	99.97%
T3172	Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.
T3730	Methyl gallate	99-24-1	99.96%
T3730	Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
T4962	Zingibroside R1	80930-74-1	99.96%
T4962	Zingibroside R1 (Ginsenoside Z-R1) has anti-HIV-1 activity.
T4S1718	Punicalin	65995-64-4	99.95%
T4S1718	Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-depende...
T41249	Tenofovir alafenamide fumarate	379270-38-9	99.95%
T41249	Tenofovir alafenamide fumarate (GS-7340 fumarate) is an orally available Tenofovir precursor compound Tenofovir alafenamide fumarate has anti-HIV activity and ca...
T4537	Cholic acid sodium	361-09-1	99.95%
T4537	Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
T10570	Fostemsavir Tris	864953-39-9	99.95%
T10570	Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency v...
T31860	Fosdevirine	1018450-26-4	99.94%
T31860	Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological re...
T0289	9-Aminoacridine	90-45-9	99.93%
T0289	9-Aminoacridine is a highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with D...
T6214	Emtricitabine	143491-57-0	99.93%
T6214	Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B ...
T0710	L-Cycloserine	339-72-0	99.92%
T0710	L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals...
T6846	Vesatolimod	1228585-88-3	99.92%
T6846	Vesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.
T16500	PF-3450074	1352879-65-2	99.92%
T16500	PF-3450074 (PF-74) acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cle...
T11451	GPI-1046	186452-09-5	99.91%
T11451	GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in ...
T1416	Zidovudine	30516-87-1	99.91%
T1416	Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in...
TP1149	HIV-1 Rev (34-50)	141237-50-5	99.91%
TP1149	HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity. HIV-1 Rev (34-50) is derived from the Rev-responsive element-b...
T9063	Clathrin-IN-1	1332879-52-3	99.91%
T9063	Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potent...