HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
TN4820	Pre-schisanartanin B	1033288-92-4	98%
TN4820	Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN5011	Shizukaol B	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T10658	CA inhibitor 1	2189684-45-3	98%
T10658	CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
T14488	Azt-pmap	142629-81-0	98%
T14488	AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI...
TN3705	Coronalolide methyl ester	268214-50-2	98%
TN3705	Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of hum...
TN4555	Methyl salvionolate A	1015171-69-3	98%
TN4555	Methyl salvionolate A has anti-HIV-1 activity.
TN4109	Ganolucidic acid A	98665-21-5	98%
TN4109	Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficien...
TN4646	Neotripterifordin	149249-32-1	98%
TN4646	Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
TN4585	Moronic acid	6713-27-5	98%
TN4585	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186)...
TN4539	Methyl chanofruticosinate	14050-92-1	98%
TN4539	Methyl chanofruticosinate has weak anti-HIV-1 activity.
TN5717	6'-O-Galloylsalidroside	83013-86-9	98%
TN5717	6'-O-Galloylsalidroside has antiviral activity and inhibits HIV.
T10296	Mavorixafor trihydrochloride	2309699-17-8	98%
T10296	Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication ...
T6589	MK-2048	869901-69-9	98%
T6589	MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
T16548	PKF050-638	528893-52-9	98%
T16548	PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. PKF050-638 is an effective and selective inhibitor of HIV-1 Rev (IC5...
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	176983-21-4	98%
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (...
TN2231	Soyasaponin II	55319-36-3	98%
TN2231	Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
T72568	HIV-1 inhibitor-53	2883496-10-2	98%
T72568	HIV-1 Inhibitor-53 is a dual inhibitor targeting both the HIV-1 protease (PR) with an IC50 value of 1.93 nM and reverse transcriptase (RT) with an IC50 of 2.35 μ...
TN2284	Triptonine B	168009-85-6	98%
TN2284	Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
T74942	HIV-1 protease-IN-7	2916441-36-4	98%
T74942	HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].
TN5177	Trigothysoid N	1501943-08-3	98%
TN5177	Trigothysoid N may have anti-HIV activity.