T5S0983 |
Absinthin
|
1362-42-1
|
|
|
Absinthin (Absynthin) is a weak HIV-1 protease inhibitor.
|
TN2186 |
Schisantherin D
|
64917-82-4
|
98%
|
|
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
|
T14208 |
AMD 3465
|
185991-24-6
|
98%
|
|
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
|
T16829 |
(S)-BI-1001
|
957889-73-5
|
98%
|
|
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
|
T78737 |
NNRTIs-IN-3
|
|
98%
|
|
NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 µM [1].
|
T78950 |
HIV-1 protease-IN-8
|
2925287-55-2
|
98%
|
|
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for ...
|
T79295 |
HIV-1 protease-IN-9
|
2925381-27-5
|
98%
|
|
HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a hal...
|
T79536 |
HIV-1 protease-IN-11
|
2925287-54-1
|
98%
|
|
HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy again...
|
T79537 |
HIV-1 protease-IN-12
|
2925287-59-6
|
98%
|
|
HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-r...
|
T79953 |
Acetyl-binankadsurin A
|
77174-33-5
|
98%
|
|
Acetyl-binankadsurin A (compound 5), a lignan obtained from Kadsura longipedunculata, exhibits weak inhibitory effects on HIV-1 protease, demonstrating an IC50 v...
|
T80112 |
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2
|
130877-92-8
|
98%
|
|
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate for the HIV-1 protease, facilitating the assessment of enzyme activity [1].
|
TN4347 |
Jacoumaric acid
|
63303-42-4
|
98%
|
|
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
|
TN3567 |
Calanolide E
|
142566-61-8
|
98%
|
|
Calanolide E2 has anti-HIV activity.
|
TN4433 |
Licoarylcoumarin
|
125709-31-1
|
98%
|
|
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
|
TN5243 |
Vitexilactone
|
61263-49-8
|
98%
|
|
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
|
T2S0605 |
Liquidambaric lactone
|
185051-75-6
|
98%
|
|
Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall.Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
|
TN1767 |
InteriotherinA
|
181701-06-4
|
98%
|
|
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
|
TN1235 |
3,4,5-Tricaffeoylquinic acid
|
86632-03-3
|
98%
|
|
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
|
TN4820 |
Pre-schisanartanin B
|
1033288-92-4
|
98%
|
|
Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
|
TN5011 |
Shizukaol B
|
142279-40-1
|
98%
|
|
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
|