Home Tools
Log in
Cart

HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5S0983 Absinthin 1362-42-1
Absinthin
Absinthin (Absynthin) is a weak HIV-1 protease inhibitor.
TN2186 Schisantherin D 64917-82-4 98%
Schisantherin D
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T14208 AMD 3465 185991-24-6 98%
AMD 3465
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
T16829 (S)-BI-1001 957889-73-5 98%
(S)-BI-1001
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T78737 NNRTIs-IN-3 98%
NNRTIs-IN-3
NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 µM [1].
T78950 HIV-1 protease-IN-8 2925287-55-2 98%
HIV-1 protease-IN-8
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for ...
T79295 HIV-1 protease-IN-9 2925381-27-5 98%
HIV-1 protease-IN-9
HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a hal...
T79536 HIV-1 protease-IN-11 2925287-54-1 98%
HIV-1 protease-IN-11
HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy again...
T79537 HIV-1 protease-IN-12 2925287-59-6 98%
HIV-1 protease-IN-12
HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-r...
T79953 Acetyl-binankadsurin A 77174-33-5 98%
Acetyl-binankadsurin A
Acetyl-binankadsurin A (compound 5), a lignan obtained from Kadsura longipedunculata, exhibits weak inhibitory effects on HIV-1 protease, demonstrating an IC50 v...
T80112 Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 130877-92-8 98%
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate for the HIV-1 protease, facilitating the assessment of enzyme activity [1].
TN4347 Jacoumaric acid 63303-42-4 98%
Jacoumaric acid
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
TN3567 Calanolide E 142566-61-8 98%
Calanolide E
Calanolide E2 has anti-HIV activity.
TN4433 Licoarylcoumarin 125709-31-1 98%
Licoarylcoumarin
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
TN5243 Vitexilactone 61263-49-8 98%
Vitexilactone
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
T2S0605 Liquidambaric lactone 185051-75-6 98%
Liquidambaric lactone
Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall.Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
TN1767 InteriotherinA 181701-06-4 98%
InteriotherinA
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
TN1235 3,4,5-Tricaffeoylquinic acid 86632-03-3 98%
3,4,5-Tricaffeoylquinic acid
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
TN4820 Pre-schisanartanin B 1033288-92-4 98%
Pre-schisanartanin B
Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN5011 Shizukaol B 142279-40-1 98%
Shizukaol B
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Absinthin
T5S0983
Absinthin (Absynthin) is a weak HIV-1 protease inhibitor.
Schisantherin D
TN2186
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
AMD 3465
T14208
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
(S)-BI-1001
T16829
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
NNRTIs-IN-3
T78737
NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 µM [1].
HIV-1 protease-IN-8
T78950
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for ...
HIV-1 protease-IN-9
T79295
HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a hal...
HIV-1 protease-IN-11
T79536
HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy again...
HIV-1 protease-IN-12
T79537
HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-r...
Acetyl-binankadsurin A
T79953
Acetyl-binankadsurin A (compound 5), a lignan obtained from Kadsura longipedunculata, exhibits weak inhibitory effects on HIV-1 protease, demonstrating an IC50 v...
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2
T80112
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate for the HIV-1 protease, facilitating the assessment of enzyme activity [1].
Jacoumaric acid
TN4347
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
Calanolide E
TN3567
Calanolide E2 has anti-HIV activity.
Licoarylcoumarin
TN4433
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
Vitexilactone
TN5243
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
Liquidambaric lactone
T2S0605
Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall.Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
InteriotherinA
TN1767
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
3,4,5-Tricaffeoylquinic acid
TN1235
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
Pre-schisanartanin B
TN4820
Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
Shizukaol B
TN5011
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
TargetMol