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HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7880 IOX4 1154097-71-8 98.87%
IOX4
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T3S2344 β,β-Dimethylacrylshikonin 24502-79-2 98.86%
β,β-Dimethylacrylshikonin
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of D...
T6823 E3330 136164-66-4 98.83%
E3330
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T1152 Albendazole 54965-21-8 98.76%
Albendazole
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2445 FG-2216 223387-75-5 98.32%
FG-2216
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo ...
T67831 HIF-2α agonist 2 2750141-15-0 98.32%
HIF-2α agonist 2
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T0256 Citric acid trilithium salt tetrahydrate 6080-58-6 98%
Citric acid trilithium salt tetrahydrate
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiat...
T5684 Ethyl 3,4-dihydroxybenzoate 3943-89-3 98%
Ethyl 3,4-dihydroxybenzoate
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
TL0001 Dencichine 5302-45-4 98%
dencichine
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggre...
T5537 IDF-11774 1429054-28-3 98%
IDF-11774
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T3180 JNJ-42041935 1193383-09-3 98%
JNJ-42041935
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T21653 1,4-DPCA 331830-20-7 97.75%
1,4-DPCA
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
T29797 AKB-6899 1007377-55-0 97.11%
AKB-6899
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T6961 PX-478 685898-44-6 97%
PX-478
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 95%
Hydroxycitric acid tripotassium hydrate
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
T1101 Minocycline hydrochloride 13614-98-7 100%
Minocycline hydrochloride
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infe...
T7802 M1001 874590-32-6 100%
M1001
M1001 is a HIF-2α agonist.
T1141 Fenbendazole 43210-67-9 100%
Fenbendazole
Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.
T50099 HIF-2α-IN-4 882268-69-1
HIF-2α-IN-4
HIF-2a translation inhibitor is a compound used as a molecular building block.
T6381 Amifostine trihydrate 112901-68-5
Amifostine trihydrate
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
IOX4
T7880
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
β,β-Dimethylacrylshikonin
T3S2344
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of D...
E3330
T6823
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
Albendazole
T1152
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
FG-2216
T2445
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo ...
HIF-2α agonist 2
T67831
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
Citric acid trilithium salt tetrahydrate
T0256
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiat...
Ethyl 3,4-dihydroxybenzoate
T5684
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
dencichine
TL0001
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggre...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
JNJ-42041935
T3180
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
1,4-DPCA
T21653
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
AKB-6899
T29797
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
PX-478
T6961
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
Hydroxycitric acid tripotassium hydrate
T11589
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
Minocycline hydrochloride
T1101
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infe...
M1001
T7802
M1001 is a HIF-2α agonist.
Fenbendazole
T1141
Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.
HIF-2α-IN-4
T50099
HIF-2a translation inhibitor is a compound used as a molecular building block.
Amifostine trihydrate
T6381
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
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TargetMol