HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.

Cat. No.	Product name	CAS No.	Purity
T14380	AZD7507	1041852-85-0	98.01%
T14380	AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.
T69534	Zongertinib	2728667-27-2	98%
T69534	Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD...
T3673	Mollugin	55481-88-4	98%
T3673	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a ...
T12542	Rilzabrutinib	1575596-29-0	97.87%
T12542	Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
T2630	Poziotinib	1092364-38-9	97.81%
T2630	Poziotinib (NOV120101)(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
T7819	TAS0728	2088323-16-2	97.78%
T7819	TAS0728 is a HER2 inhibitor, with antitumor activity
T13088	Tarloxotinib bromide	1636180-98-7	97.15%
T13088	Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.
T30260	AZD-5672	780750-65-4	95.58%
T30260	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
T8189	Dihydroberberine	483-15-8	93.77%
T8189	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
T2325	Neratinib	698387-09-6	100%
T2325	Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T5390	BMS-599626 Hydrochloride	873837-23-1	100%
T5390	BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respecti...
T12912	Sigma-1 receptor antagonist 3	1639220-17-9	100%
T12912	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T8182	Guanfu base A	1394-48-5	98%
T8182	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T4612	NS309	18711-16-5	98%
T4612	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
T35901	EGFR-IN-99	2068806-31-3	98%
T35901	EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (...
T76796	Patritumab	1262787-83-6	98%
T76796	Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
T11966	MCHR1 antagonist 2	863115-70-2	98%
T11966	MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
T6341	PF04929113	908115-27-5	98%
T6341	PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF0492911...
T2610L	BMS-599626 2HCL(714971-09-2 Free base)	1781932-33-9	98%
T2610L	BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 ...