HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.

Cat. No.	Product name	CAS No.	Purity
T22431	SU5204	186611-11-0	99.5%
T22431	SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and ...
T1291	Cisapride	81098-60-4	99.5%
T1291	Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote int...
T11213	Epertinib hydrochloride	2071195-74-7	99.36%
T11213	Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective ty...
T1266	Terfenadine	50679-08-8	99.36%
T1266	Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist...
T6039	TAK-285	871026-44-7	99.17%
T6039	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Auro...
T3108	CUDC-101	1012054-59-9	99.12%
T3108	CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.
T33876L	Panomifene HCl		99.09%
T33876L	Panomifene HCl is a selective anti-estrogenic compound with antitumor activity for the treatment of breast cancer.
T6341	PF04929113	908115-27-5	99.06%
T6341	PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF0492911...
T6712	Tyrphostin AG 879	148741-30-4	99.05%
T6712	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
T2047	AG-1478	153436-53-4	99.03%
T2047	AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T16444	PD-118057	313674-97-4	98.97%
T16444	PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
T4694	AG-1557 hydrochloride (189290-58-2(free base))	T4694	98.95%
T4694	AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
T4075	Sulfatinib	1308672-74-3	98.93%
T4075	Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24...
T9072	Tuxobertinib	2414572-47-5	98.86%
T9072	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK a...
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T2034	AG1557	189290-58-2	98.62%
T2034	AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
T34760	SYR127063	871026-18-5	98.57%
T34760	SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
T4342	PF-04929113 Mesylate	1173111-67-5	98.38%
T4342	PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 ...
T3192	NS1643	448895-37-2	98.37%
T3192	NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
T4S0544	Furanodienone	24268-41-5	98.32%
T4S0544	1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...