HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.

Cat. No.	Product name	CAS No.	Purity
T2610	BMS-599626	714971-09-2	98.79%
T2610	BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T14677	BMS-690514	859853-30-8	98%
T14677	BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
T6827	Endoxifen Z-isomer hydrochloride	1032008-74-4	98%
T6827	Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T11213L	Epertinib	908305-13-5	98%
T11213L	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
TP1583L	HER2/neu (654-662) GP2 acetate	TP1583L	98%
TP1583L	HER2/neu (654-662) GP2 acetate is derived from the human epidermal growth factor receptor 2 (HER2-Neu, 654–662). HER2/neu (654-662) GP2 acetate induces HLA-A2-re...
T0801	Tannic acid	1401-55-4	AR
T0801	Tannic acid (Gallotannic acid) is a novel hERG channel blocker.
T2303	(S)-Afatinib	439081-18-2	99.96%
T2303	(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, r...
T2364	Tucatinib	937263-43-9	99.96%
T2364	Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
T5398	BMS 599626 2HCl (873837-23-1(HCl))	T5398	99.94%
T5398	BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100-...
TN1092	O-Nornuciferine	3153-55-7	99.86%
TN1092	O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
T8182	Guanfu base A	1394-48-5	99.85%
T8182	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T2280	Endoxifen (Z-isomer)	112093-28-4	99.81%
T2280	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
T9009	ICA-105574	316146-57-3	99.77%
T9009	ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action poten...
T12542	Rilzabrutinib	1575596-29-0	99.76%
T12542	Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
TQ0139	VU 0240551	893990-34-6	99.72%
TQ0139	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
T6719	Varlitinib	845272-21-1	99.7%
T6719	Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.
T9304	(S)-Sunvozertinib	2370013-49-1	99.69%
T9304	(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
T1773	Afatinib Dimaleate	850140-73-7	99.66%
T1773	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth f...
T67385	Neratinib maleate	915942-22-2	99.64%
T67385	Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respec...
T3554	RG14620	136831-49-7	99.56%
T3554	RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.