HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T2512	Mocetinostat	726169-73-9	99.37%
T2512	Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.
TN1911	Marein	535-96-6	99.34%
TN1911	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
T2140	Parthenolide	20554-84-1	99.33%
T2140	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions...
T6161	Tubastatin A Hydrochloride	1310693-92-5	99.25%
T6161	Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes excep...
T6061	LMK-235	1418033-25-6	99.24%
T6061	LMK-235 is a potent HDAC inhibitor, and is used in cancer research.
T10244	ACY-1083	1708113-43-2	99.22%
T10244	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.
T7052	Gnetol	86361-55-9	99.21%
T7052	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly sup...
T9148	KA2507	1636894-46-6	99.14%
T9148	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
T73515	MC2590	2284460-01-9	99.14%
T73515	MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes ...
T6325	PCI-34051	950762-95-5	99.14%
T6325	PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).
T2383	Panobinostat	404950-80-7	99.14%
T2383	Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces ...
T3108	CUDC-101	1012054-59-9	99.12%
T3108	CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.
T77664	KH16		99.11%
T77664	KH16 is a potent HDAC inhibitor that specifically targets class I HDACs (HDAC1, HDAC2 and HDAC3) with IC50 values between 6 and 34 nM. KH16 is able to stimulate ...
T6233	Entinostat	209783-80-2	99.11%
T6233	Entinostat (MS-275) (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM).
T6286	RGFP966 (E-isomer)	1396841-57-8	99.1%
T6286	RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.
T10602L	BRD 4354	315698-07-8	99.08%
T10602L	BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively.
T30579	BRD4097	1550053-19-4	99.08%
T30579	BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insuli...
T16936	SS-208	2245942-72-5	99.07%
T16936	SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
T3661	Citarinostat	1316215-12-9	99.06%
T3661	ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic act...
T3878	Raddeanin A	89412-79-3	99.05%
T3878	Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.