HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T79543	J27644		98%
T79543	J27644 is a potent HDAC (histone deacetylase) inhibitor that mitigates TGF-β (transforming growth factor beta)-induced pulmonary fibrosis [1].
T79674	HDAC-IN-64		98%
T79674	HDAC-IN-64 (Compound 13), an HDAC inhibitor, demonstrates potent inhibition of HDAC4/5/6/7/9 with IC50 values of 24, 45, 85, 31, and 37 nM, respectively. It exhi...
T79710	PI3Kα/HDAC6-IN-1		98%
T79710	PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser4...
T79713	JMJD3/HDAC-IN-1	2883046-06-6	98%
T79713	Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone dea...
T79714	HDAC3-IN-2		98%
T79714	HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells. Demonstrati...
T79769	HDAC6-IN-23		98%
T79769	HDAC6-IN-23 (compound 9), an orally active inhibitor of HDAC6 [1], displays selective enzymatic inhibition.
T79771	HDAC6-IN-22		98%
T79771	HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro and ...
T79839	Bocodepsin	1834513-65-3	98%
T79839	Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy. It is indicated for the treatme...
T79840	Bocodepsin hydrochloride	1834513-66-4	98%
T79840	Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration. It is employed in the suppressio...
T81392	PRO-HD3		98%
T81392	PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].
T81393	PRO-HD2		98%
T81393	PRO-HD2 is a selective, PROTAC-based degrader of HDAC6 [1].
T81394	PRO-HD1		98%
T81394	PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50 of...
T81725	Mz325		98%
T81725	Mz325 serves as a dual inhibitor of both HDAC and Sirt2, exhibiting an IC50 of 9.7 µM against Sirt2, which are implicated in the pathogenesis of cancer and neuro...
T81974	KPZ560	2397562-43-3	98%
T81974	KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively. This compound enhances spine density in mouse granule neuron...
T82224	HDAC6-IN-25		98%
T82224	HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor, exhibiting an IC50 value of 0.6 nM [1].
T82225	HDAC6-IN-24		98%
T82225	HDAC6-IN-24 (compound N1) is an inhibitor of histone deacetylase 6 (HDAC6) [1].
T82226	HDAC6-IN-21	2920929-76-4	98%
T82226	HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].
T82227	HDAC1/CDK7-IN-1	2987905-95-1	98%
T82227	HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effe...
T82313	GK718		98%
T82313	GK718, a selective HDAC1/3 inhibitor with IC50 values of 259 nM and 139 nM, respectively, elevates acetylated histone H3 levels in cells and mitigates Bleomycin-...
T82314	GK444		98%
T82314	GK444 (Compound 15a), a selective HDAC1/2 inhibitor with IC50 values of 100 nM and 92 nM for HDAC1 and HDAC2 respectively, demonstrates an IC50 of 4.1 μM in Caco...