HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T77732	HFY-4A	2094810-82-7	98%
T77732	HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.
T77937	JPS014 TFA		98%
T77937	JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), ...
T77938	JPS016 TFA		98%
T77938	JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), part...
T78709	NT160	1418293-40-9	98%
T78709	NT160, a potent class-IIa HDAC inhibitor, exhibits an IC50 of 0.046 μM and has potential applications in central nervous system disease research [1].
T78766	HDAC-IN-59	2944459-43-0	98%
T78766	HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage, ar...
T78767	HDAC-IN-60	2944459-58-7	98%
T78767	HDAC-IN-60 (compound 21a), a potent histone deacetylase (HDAC) inhibitor, promotes intracellular reactive oxygen species (ROS) production, induces DNA damage, ar...
T78768	HDAC6-IN-16		98%
T78768	HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony format...
T78769	HDAC6-IN-17		98%
T78769	HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates c...
T78799	BChE/HDAC6-IN-1	2925457-27-6	98%
T78799	BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstra...
T78839	HDAC6-IN-19		98%
T78839	HDAC6-IN-19 (Compound 14g), an HDAC6 inhibitor with an IC50 of 2.68 nM, additionally inhibits HDAC1, HDAC2, and HDAC3, with IC50 values of 61.6 nM, 98.7 nM, and ...
T78861	HDAC8-IN-5		98%
T78861	HDAC8-IN-5 (Compound 6a), with an inhibitory concentration (IC50) of 28 nM, is a potent HDAC8 inhibitor suitable for cancer research [1].
T78906	CDK/HDAC-IN-3	2944087-54-9	98%
T78906	CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with...
T78920	HDAC-IN-58	2071224-39-8	98%
T78920	HDAC-IN-58, a selective HDAC6 inhibitor, exhibits potent inhibitory activity with an IC50 of 2.06 nM, rendering it suitable for research into chronic neurodegene...
T78969	PB131	2924425-63-6	98%
T78969	PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable f...
T79003	HDAC ligand-1	34840-28-3	98%
T79003	HDAC ligand-1 is a synthetic precursor utilized in the production of PROTAC-based HDAC degraders [1].
T79082	HDAC8-IN-4	1600528-05-9	98%
T79082	HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].
T79366	SP-2-225	2364448-93-9	98%
T79366	SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells, de...
T79523	HDAC6-IN-18		98%
T79523	HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects. It demonstrates HDAC6 inhibitory ...
T79541	HDAC-IN-61		98%
T79541	HDAC-IN-61 (compound 12k) is a potent, orally active inhibitor of histone deacetylase (HDAC) with anticancer activity, exhibiting an IC50 of 30 nM against Bel-74...
T79542	SGC-UBD253		98%
T79542	SGC-UBD253 is a potent antagonist of the HDAC6-UBD interaction and may be utilized in cancer research [1].