T60224 |
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
|
175340-21-3
|
99.69%
|
|
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986. S 18986 is a AMPA receptor positive modu...
|
T65135 |
Kynurenic acid
|
492-27-3
|
99.69%
|
|
Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and ...
|
T6727 |
VU0364770
|
61350-00-3
|
99.66%
|
|
VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subt...
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T22638 |
CBiPES hydrochloride
|
856702-40-4
|
99.66%
|
|
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of...
|
T0024 |
Primidone
|
125-33-7
|
99.66%
|
|
Primidone (NCI-C56360) is a potent anticonvulsant agent. It is a neuronal voltage-gated sodium channel blocker and has value in the study of epilepsy, essential ...
|
T29126 |
VU0360172
|
1310012-12-4
|
99.65%
|
|
VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).
|
T23215L |
(R)-3,4-DCPG HCl
|
T23215L
|
99.64%
|
|
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal ...
|
T0051 |
Urethane
|
51-79-6
|
99.63%
|
|
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
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T37734 |
AMPA receptor modulator-2
|
2034181-36-5
|
99.62%
|
|
AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50.
[1]. BERRY CYN...
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T10881 |
CPPHA
|
693288-97-0
|
99.61%
|
|
CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.
|
TQ0094 |
JNJ-40411813
|
1127498-03-6
|
99.57%
|
|
JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
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T21995 |
XAP044
|
196928-50-4
|
99.56%
|
|
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal block...
|
T5509 |
FPTQ
|
864863-72-9
|
99.56%
|
|
FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1]. In addition to its robus...
|
T11032 |
DHPG
|
146255-66-5
|
99.55%
|
|
DHPG ((RS)-3,5-DHPG) ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. It is an amino acid that can be used as a selective and poten...
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T11393 |
GET73
|
202402-01-5
|
99.54%
|
|
GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol...
|
T3484 |
Trans-ACPD
|
67684-64-4
|
99.53%
|
|
trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate re...
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T10573 |
BMT-145027
|
2018282-44-3
|
99.5%
|
|
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).
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T10432L |
AZD-8529 mesylate
|
1314217-69-0
|
99.5%
|
|
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulato...
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T8626 |
Transtorine
|
13593-94-7
|
99.49%
|
|
Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) is a GluR and NMDA inhibitor.
|
T8779 |
HBT1
|
489408-02-8
|
99.48%
|
|
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons....
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