GSK-3

Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways. In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (diabetes mellitus type 2), Alzheimer's disease, inflammation, cancer, and bipolar disorder.

Cat. No.	Product name	CAS No.	Purity
T11468	GSK-3 inhibitor 1	603272-51-1
T11468	GSK-3 inhibitor 1 is a GSK-3 inhibitor.
T79693	PIMPC	2250244-44-9	98%
T79693	PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits potentia...
T80124	C-Peptide 1 (rat)	41475-27-8	98%
T80124	C-Peptide 1 (rat), a β-catenin/GSK-3β activator and regulator of the Wnt/β-catenin signaling pathway, is utilized in cancer research [1].
T82243	HAChE-IN-5		98%
T82243	hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency with I...
TN4263	Isoangustone A	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN3319	9-Hydroxycanthin-6-one	138544-91-9	98%
TN3319	9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
T10172	5-Iodo-indirubin-3'-monoxime	331467-03-9	98%
T10172	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s:...
T2S0606	Bakkenolide A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T10786	Charantin	57126-62-2	98%
T10786	Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
TN4637	Neogrifolin	23665-96-5	98%
TN4637	Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
TN2995	4,10-Aromadendranediol	70051-38-6	98%
TN2995	4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TMA0291	Dehydroglyasperin D	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN4046	Excisanin A	78536-37-5	98%
TN4046	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T35556	GSK-3β inhibitor 8	1139875-74-3	98%
T35556	GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine deriva...
T11960	MBM-55	2083622-09-5	99.98%
T11960	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
T1260	Cromolyn sodium	15826-37-6	99.95%
T1260	Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
T1881	AR-A014418	487021-52-3	99.94%
T1881	AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.
T6940	PHA-767491 hydrochloride	942425-68-5	99.92%
T6940	PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against...
T1965	Bikinin	188011-69-0	99.91%
T1965	Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.