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GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11461 NE 52-QQ57 1401728-56-0 99.93%
NE 52-QQ57
NE 52-QQ57 is a selective, and orally available antagonist of GPR4(IC50 : 70 nM),with anti-inflammatory activity.
TP1666L Kisspeptin-10, rat acetate(478507-53-8 free base) TP1666L 99.92%
Kisspeptin-10, rat acetate(478507-53-8 free base)
Kisspeptin-10, rat acetate is an endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54).
T22027 AH-7614 6326-06-3 99.91%
AH-7614
AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
T2664 Timapiprant 851723-84-7 99.89%
Timapiprant
Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
T3176 APD597 897732-93-3 99.87%
APD597
APD597 (JNJ-38431055) is a GPR119 agonist, used in the treatment of type 2 diabetes.
T3171 GSK137647A 349085-82-1 99.87%
GSK137647A
GSK137647A (GSK 137647) is a selective FFA4 agonist.
T22591 ATC 0175 hydrochloride 510733-97-8 99.84%
ATC 0175 hydrochloride
ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affini...
T4626 TC-O 9311 free base 99.81%
TC-O 9311 free base
TC-O 9311 is a potent GPR139 agonist.
T4566 Lodoxamide 53882-12-5 99.81%
Lodoxamide
Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
TN2077 (+/-)-Pinocembrin 68745-38-0 99.79%
(+/-)-Pinocembrin
(+/-)-Pinocembrin (NSC-43318), a natural product from axillary pines, is a GPR120 ligand that promotes wound healing in the HaCaT cell line.
T33452 ML192 460331-61-7 99.79%
ML192
ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII transloca...
T2528 Latanoprost 130209-82-4 99.78%
Latanoprost
Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.
T19700 IBC 293 306935-41-1 99.74%
IBC 293
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expre...
T11458 GPR40/FFAR1 modulator 1 874755-26-7 99.72%
GPR40/FFAR1 modulator 1
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator.
T10691 CAY10595 916047-16-0 99.71%
CAY10595
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.
T3919 Ginsenoside Rb2 11021-13-9 99.66%
Ginsenoside Rb2
Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.
T12375 Fezagepras sodium 1254472-97-3 99.59%
Fezagepras sodium
Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflamma...
T60184 TUG-499 1206629-08-4 99.59%
TUG-499
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
T27850 LP-471756 413605-11-5 99.59%
LP-471756
LP-471756 is a specific antagonist of GPR139 and inhibits LP-360924-stimulated cAMP production (IC50 = 640 nM).
T15388 GLPG0974 1391076-61-1 99.58%
GLPG0974
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
NE 52-QQ57
T11461
NE 52-QQ57 is a selective, and orally available antagonist of GPR4(IC50 : 70 nM),with anti-inflammatory activity.
Kisspeptin-10, rat acetate(478507-53-8 free base)
TP1666L
Kisspeptin-10, rat acetate is an endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54).
AH-7614
T22027
AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
Timapiprant
T2664
Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
APD597
T3176
APD597 (JNJ-38431055) is a GPR119 agonist, used in the treatment of type 2 diabetes.
GSK137647A
T3171
GSK137647A (GSK 137647) is a selective FFA4 agonist.
ATC 0175 hydrochloride
T22591
ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affini...
TC-O 9311 free base
T4626
TC-O 9311 is a potent GPR139 agonist.
Lodoxamide
T4566
Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
(+/-)-Pinocembrin
TN2077
(+/-)-Pinocembrin (NSC-43318), a natural product from axillary pines, is a GPR120 ligand that promotes wound healing in the HaCaT cell line.
ML192
T33452
ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII transloca...
Latanoprost
T2528
Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.
IBC 293
T19700
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expre...
GPR40/FFAR1 modulator 1
T11458
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator.
CAY10595
T10691
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.
Ginsenoside Rb2
T3919
Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.
Fezagepras sodium
T12375
Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflamma...
TUG-499
T60184
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
LP-471756
T27850
LP-471756 is a specific antagonist of GPR139 and inhibits LP-360924-stimulated cAMP production (IC50 = 640 nM).
GLPG0974
T15388
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
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TargetMol