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Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0935 Butylated hydroxytoluene 128-37-0 100%
Butylated hydroxytoluene
Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.
T6954 PRIMA-1 5608-24-2
PRIMA-1
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
T7708 DL-Buthionine-(S,R)-sulfoximine 5072-26-4
DL-Buthionine-(S,R)-sulfoximine
DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
T0326 DL-Glutamine 6899-04-3
DL-Glutamine
DL-Glutamine (2-amino-4-carbamoylbutanoic acid), a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processe...
T1885 Siramesine hydrochloride 224177-60-0
Siramesine hydrochloride
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit ...
T2887 Trigonelline 535-83-1
Trigonelline
Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
T20819 Ammonium iron(III) citrate 1185-57-5
Ammonium iron(III) citrate
Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellul...
T6871 L-Glutamic acid monosodium salt 142-47-2
L-Glutamic acid monosodium salt
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
T0078L Lapatinib ditosylate monohydrate 388082-78-8
Lapatinib ditosylate monohydrate
Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumor...
T5523 Imidazole ketone erastin 1801530-11-9 98%
Imidazole ketone erastin
Imidazole ketone erastin (IKE) is an iron death inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has...
T2401 Alogliptin Benzoate 850649-62-6 98%
Alogliptin Benzoate
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alog...
T6821 Dp44mT 152095-12-0 98%
Dp44mT
Dp44mT, a effective iron chelator, has selective antitumor activity.
T60084 FINO2 869298-31-7 98%
FINO2
FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrati...
T1934 Bay 11-7085 196309-76-9 98%
Bay 11-7085
Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
Butylated hydroxytoluene
T0935
Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.
PRIMA-1
T6954
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
DL-Buthionine-(S,R)-sulfoximine
T7708
DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
DL-Glutamine
T0326
DL-Glutamine (2-amino-4-carbamoylbutanoic acid), a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processe...
Siramesine hydrochloride
T1885
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit ...
Trigonelline
T2887
Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
Ammonium iron(III) citrate
T20819
Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellul...
L-Glutamic acid monosodium salt
T6871
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
Lapatinib ditosylate monohydrate
T0078L
Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumor...
Imidazole ketone erastin
T5523
Imidazole ketone erastin (IKE) is an iron death inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has...
Alogliptin Benzoate
T2401
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alog...
Dp44mT
T6821
Dp44mT, a effective iron chelator, has selective antitumor activity.
FINO2
T60084
FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrati...
Bay 11-7085
T1934
Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
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TargetMol