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Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T19467 NADPH tetracyclohexanamine 100929-71-3 99.05%
NADPH tetracyclohexanamine
NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.
T2O2733 L-Cystine 56-89-3 99%
L-Cystine
L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cyste...
T5523 Imidazole ketone erastin 1801530-11-9 98.98%
Imidazole ketone erastin
Imidazole ketone erastin (IKE) (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter.
T1516 Curcumin 458-37-7 98.98%
Curcumin
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
T1114 Ciclopirox olamine 41621-49-2 98.97%
Ciclopirox olamine
Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
T6165 Bardoxolone Methyl 218600-53-4 98.94%
Bardoxolone Methyl
Bardoxolone Methyl (TP-155), an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T1710 Trolox 53188-07-1 98.9%
Trolox
Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.
T4360 ML385 846557-71-9 98.88%
ML385
ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhib...
T4414 Eprenetapopt 5291-32-7 98.75%
Eprenetapopt
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenopr...
T1085 L-Glutathione reduced 70-18-8 98.72%
L-Glutathione reduced
L-Glutathione reduced (Glutathione) is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for s...
T8922 SRS11-92 1467047-25-1 98.67%
SRS11-92
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1
T5343 UAMC-3203 2271358-64-4 98.55%
UAMC-3203
UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).
T2707 Pifithrin-α hydrobromide 63208-82-2 98.54%
Pifithrin-α hydrobromide
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
TJS1159 Chrysosplenetin 603-56-5 98.53%
Chrysosplenetin
Chrysosplenetin is a metabolic inhibitor of artemisinin.
TQ0120 CDDO-Im 443104-02-7 98.3%
CDDO-Im
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T7092 NADPH tetrasodium salt 2646-71-1 98.22%
NADPH tetrasodium salt
NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various ...
T2988 (-)-Epigallocatechin Gallate 989-51-5 98.08%
(-)-Epigallocatechin Gallate
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG...
T0907 Sulfasalazine 599-79-1 98.05%
Sulfasalazine
Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T0423 Ethylenediaminetetraacetic acid trisodium salt 150-38-9 98%
Ethylenediaminetetraacetic acid trisodium salt
Ethylenediaminetetraacetic acid trisodium salt (EDTA Trisodium) used to bind metal ions in the chelation therapy.
T2856 (-)-Epicatechin 490-46-0 98%
(-)-Epicatechin
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization o...
NADPH tetracyclohexanamine
T19467
NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.
L-Cystine
T2O2733
L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cyste...
Imidazole ketone erastin
T5523
Imidazole ketone erastin (IKE) (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter.
Curcumin
T1516
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
Ciclopirox olamine
T1114
Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
Bardoxolone Methyl
T6165
Bardoxolone Methyl (TP-155), an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
Trolox
T1710
Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.
ML385
T4360
ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhib...
Eprenetapopt
T4414
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenopr...
L-Glutathione reduced
T1085
L-Glutathione reduced (Glutathione) is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for s...
SRS11-92
T8922
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1
UAMC-3203
T5343
UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).
Pifithrin-α hydrobromide
T2707
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
Chrysosplenetin
TJS1159
Chrysosplenetin is a metabolic inhibitor of artemisinin.
CDDO-Im
TQ0120
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
NADPH tetrasodium salt
T7092
NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various ...
(-)-Epigallocatechin Gallate
T2988
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG...
Sulfasalazine
T0907
Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
Ethylenediaminetetraacetic acid trisodium salt
T0423
Ethylenediaminetetraacetic acid trisodium salt (EDTA Trisodium) used to bind metal ions in the chelation therapy.
(-)-Epicatechin
T2856
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization o...
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TargetMol