T63042 |
NDB
|
1660153-08-1
|
98.94%
|
|
NDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes....
|
T78910 |
ZLY28
|
|
98%
|
|
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1. Additionally, it ...
|
T81030 |
Tauro-β-muricholic acid
|
25696-60-0
|
98%
|
|
Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic effe...
|
TN4628 |
Nelumol A
|
77836-86-3
|
98%
|
|
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
|
T11426 |
Gly-β-MCA
|
66225-78-3
|
98%
|
|
Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes....
|
T15818 |
LY367385
|
198419-91-9
|
98%
|
|
LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
|
T13093 |
Tauro-β-muricholic acid sodium
|
145022-92-0
|
98%
|
|
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
|
T2202 |
Lithocholic acid
|
434-13-9
|
99.98%
|
|
Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It a...
|
T2233 |
GW 4064
|
278779-30-9
|
99.94%
|
|
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
|
TQ0252 |
BAR502
|
1612191-86-2
|
99.91%
|
|
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
|
T1789 |
Obeticholic Acid
|
459789-99-2
|
99.88%
|
|
Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
|
T13092 |
Tauro-Obeticholic acid
|
863239-61-6
|
99.82%
|
|
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
|
T7886 |
Nidufexor
|
1773489-72-7
|
99.79%
|
|
Nidufexor is an agonist for the farnesoid X receptor (FXR).
|
T15806 |
LY2562175
|
1103500-20-4
|
99.78%
|
|
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
|
T0847 |
Chenodeoxycholic acid
|
474-25-9
|
99.72%
|
|
Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorpti...
|
T31587 |
DY268
|
1609564-75-1
|
99.43%
|
|
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 =...
|
T6690 |
T0901317
|
293754-55-9
|
99.43%
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
|
T4379 |
Tropifexor
|
1383816-29-2
|
99.3%
|
|
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
|
T2015 |
Fexaramine
|
574013-66-4
|
98.87%
|
|
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
|
T2939 |
Forskolin
|
66575-29-9
|
98.83%
|
|
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces auto...
|