T64370 |
JI6
|
856436-16-3
|
97.74%
|
|
JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, ...
|
T1836 |
AZD2932
|
883986-34-3
|
97.71%
|
|
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.
|
T6174 |
R406
|
841290-81-1
|
97.67%
|
|
R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
|
T16750 |
Rigosertib
|
592542-59-1
|
97.33%
|
|
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer a...
|
T38562 |
AKN-028
|
1175017-90-9
|
97.3%
|
|
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
|
T5164 |
Cabozantinib hydrochloride
|
1817759-42-4
|
97.09%
|
|
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM...
|
T13564 |
AZ7550
|
1421373-99-0
|
97.07%
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
T6458 |
CYC-116
|
693228-63-6
|
96.6%
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
|
T15335 |
FN-1501
|
1429515-59-2
|
96.35%
|
|
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1...
|
T35570 |
Chiauranib
|
1256349-48-0
|
96.25%
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
|
T4428 |
CCT241736
|
1402709-93-6
|
96.2%
|
|
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, ...
|
T3621 |
Brigatinib
|
1197953-54-0
|
100%
|
|
Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.
|
T20743 |
TG-46
|
936091-15-5
|
100%
|
|
TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.
|
T8317 |
5'-Fluoroindirubinoxime
|
861214-33-7
|
100%
|
|
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).
|
T7104 |
Dovitinib lactate
|
692737-80-7
|
100%
|
|
Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
|
T2116 |
AEE788
|
497839-62-0
|
|
|
AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
|
T1667 |
Tandutinib
|
387867-13-2
|
|
|
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus...
|
T7673 |
ATH686
|
853299-52-2
|
|
|
ATH686 is an potent and selective Inhibitor of FLT3.
|
T2054 |
Altiratinib
|
1345847-93-9
|
98%
|
|
Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, c...
|
TQ0317 |
R1530
|
882531-87-5
|
98%
|
|
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
|