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FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4606 2119738-71-3 2119738-71-3 99.23%
2119738-71-3
2119738-71-3 is a useful organic compound for research related to life sciences. The catalog number is T4606 and the CAS number is 2119738-71-3.
T64167 Ifebemtinib 1227948-82-4 98.33%
Ifebemtinib
Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule form...
T15092 Defactinib hydrochloride 1073160-26-5 98.06%
Defactinib hydrochloride
Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-depen...
T79688 FAK-IN-11 98%
FAK-IN-11
FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation. It exhibits cytotoxic effects on MDA...
T82420 FAK-IN-12 98%
FAK-IN-12
FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM. It effectively suppresses proliferation of MGC-803, HCT-116, and KYSE30 cells with I...
T6936 PF-03814735 942487-16-3 98%
PF-03814735
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
TN3139 5α-Hydroxycostic acid 132185-83-2 98%
5α-Hydroxycostic acid
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T11260 FAK inhibitor 2 2354405-14-2 98%
FAK inhibitor 2
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
TN4046 Excisanin A 78536-37-5 98%
Excisanin A
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T2609 Masitinib 790299-79-5 99.91%
Masitinib
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
TQ0169 Inulicin 33627-41-7 99.77%
Inulicin
Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T1950 PND-1186 1061353-68-1 99.75%
PND-1186
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
T9576 AMP-945 1393653-34-3 99.60%
AMP-945
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
T2809 (R)-Fangchinoline 33889-68-8 99.58%
(R)-Fangchinoline
(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.
T3391 Corosolic acid 4547-24-4 99.52%
Corosolic acid
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activ...
T6177 PF-562271 besylate 939791-38-5 99.5%
PF-562271 besylate
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK a...
T0263 Chloropyramine hydrochloride 6170-42-9 99.45%
Chloropyramine hydrochloride
Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.
T67843 GSK215 2743427-26-9 99.3%
GSK215
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
T6419 BMS-536924 468740-43-4 99.19%
BMS-536924
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for ...
TN1433 Batatasin III 56684-87-8 99.16%
Batatasin III
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities...
2119738-71-3
T4606
2119738-71-3 is a useful organic compound for research related to life sciences. The catalog number is T4606 and the CAS number is 2119738-71-3.
Ifebemtinib
T64167
Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule form...
Defactinib hydrochloride
T15092
Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-depen...
FAK-IN-11
T79688
FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation. It exhibits cytotoxic effects on MDA...
FAK-IN-12
T82420
FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM. It effectively suppresses proliferation of MGC-803, HCT-116, and KYSE30 cells with I...
PF-03814735
T6936
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
5α-Hydroxycostic acid
TN3139
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
FAK inhibitor 2
T11260
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Masitinib
T2609
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
Inulicin
TQ0169
Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
PND-1186
T1950
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
AMP-945
T9576
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
(R)-Fangchinoline
T2809
(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.
Corosolic acid
T3391
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activ...
PF-562271 besylate
T6177
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK a...
Chloropyramine hydrochloride
T0263
Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.
GSK215
T67843
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
BMS-536924
T6419
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for ...
Batatasin III
TN1433
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities...
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TargetMol